Differential distribution of intravenous curcumin formulations in the rat brain

Simon S. Chiu, Edmund Lui, Muhammed Majeed, Jamboor K. Vishwanatha, Amalendu P. Ranjan, Anirban Maitra, Dipanker Pramanik, Judith A. Smith, Lawrence Helson

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Background: The neuropathic side-effects of trauma, stroke or therapeutic radiation of the brain for life-threatening neoplastic diseases are the result of damage to normal tissues resulting in defects in cognition and memory. Based upon published preclinical data of curcumin activity application of parenteral curcumin formulations may prove to be to be promising chemotherapy for disorders following neuropathic insults. Studies in in vitro and animal models suggest curcumin may be an effective remediative agent for brain damage. The initial steps in curcumin development for clinical applications to neuropathic disorders are formulating it for intravenous administration, determining the formulated product passes the blood-brain barrier and reaches therapeutic amounts in damaged areas in the brain with tolerable safety. Following intravenous administration of liposomal curcumin, polymeric nanocurcumin and polylactic glycolic acid co-polymer (PLGA)-curcumin in rats, these formulations were observed to cross the blood-brain barrier using a sensitive HPLC assay. All three formulations localized in specific sites in the brain without observable adverse events. One hour following intravenous injection of 5 mg/kg nanocurcumin, or 20 mg/kg PLGA-curcumin, or liposomal curcumin, up to 0.5% of the injected material localized in the brain stem, the striatum, and the hippocampus with varied accumulation and clearance rates. Conclusion: These data indicate that curcumin does localize in putative damaged brain tissues and suggest therapeutic trials be explored with all three formulations in animal models with pre- and post traumatic states.

Original languageEnglish
Pages (from-to)907-911
Number of pages5
JournalAnticancer Research
Volume31
Issue number3
StatePublished - Mar 2011

Keywords

  • Blood-brain barrier
  • Brain stem
  • Hippocampus
  • Intravenous curcumin
  • Post-traumatic sequelae
  • Striatum

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  • Cite this

    Chiu, S. S., Lui, E., Majeed, M., Vishwanatha, J. K., Ranjan, A. P., Maitra, A., Pramanik, D., Smith, J. A., & Helson, L. (2011). Differential distribution of intravenous curcumin formulations in the rat brain. Anticancer Research, 31(3), 907-911.