Dichloroacetonitrile, a by-product of water chlorination, induces aneuploidy in Drosophila

C. Osgood, David Sterling

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Nitriles have been shown to be potent inducers of aneuploidy in yeast and Drosophila test systems. Haloacetonitriles are by-products of water chlorination that have been shown to be mutagenic and carcinogenic following topical application. In this report we show that dichloroacetonitrile, but not dibromoacetonitrile, is an effective inducer of aneuploidy in oocytes of Drosophila melanogaster. Following inhalation exposure of ZESTE adult females, dichloroacetonitrile (8.6 ppm) induced highly significant increments in the frequencies of sex chromosome loss and gain. Sodium cyanide was also found to be a highly effective inducer of germline aneuploidy, suggesting that cyanide toxicity may contribute to potency of nitriles as inducers of aneuploidy.

Original languageEnglish
Pages (from-to)85-91
Number of pages7
JournalMutation Research/Genetic Toxicology
Volume261
Issue number2
DOIs
StatePublished - 1 Jan 1991

Fingerprint

Nitriles
dibromoacetonitrile
Chlorination
Halogenation
Aneuploidy
Drosophila
Byproducts
Sodium Cyanide
Water
Cyanides
Yeast
Toxicity
Inhalation Exposure
Sex Chromosomes
Drosophila melanogaster
Oocytes
Yeasts
dichloroacetonitrile

Keywords

  • (Drosophila melanogaster)
  • Aneuploidy
  • Dichloroacetonitrile
  • Haloacetonitriles
  • Water chlorination

Cite this

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Dichloroacetonitrile, a by-product of water chlorination, induces aneuploidy in Drosophila. / Osgood, C.; Sterling, David.

In: Mutation Research/Genetic Toxicology, Vol. 261, No. 2, 01.01.1991, p. 85-91.

Research output: Contribution to journalArticle

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