Abstract
Changes in the spontaneous motor activity and locomotor activity, after chronic intake of diazepam and ethanol were studied in young and old rats. The spontaneous motor activity and locomotor activity decreased in all the treated rats of both the age groups. The decrease in motor activity was greater following ethanol ingestion when compared with diazepam treatment and it was further augmented in combined administration of both drugs. Severe impairment was recorded in the senile rats when compared with the young groups. These results suggest that diazepam and ethanol produce motor debilities which are potentiated on combined drug treatment and also during senescence.
| Original language | English |
|---|---|
| Pages (from-to) | 141-148 |
| Number of pages | 8 |
| Journal | Biomedical Letters |
| Volume | 60 |
| Issue number | 236 |
| State | Published - 1 Dec 1999 |
Keywords
- Aging
- Diazepam
- Ethanol
- Locomotor activity
- Spontaneous motor activity