Diazepam and etlhanol induced motor deficits in white rats during aging

Md Riyaz Basha, L. Madhusudhana, Y. Sreenivasulu, G. Rajarami Reddy

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1 Scopus citations

Abstract

Changes in the spontaneous motor activity and locomotor activity, after chronic intake of diazepam and ethanol were studied in young and old rats. The spontaneous motor activity and locomotor activity decreased in all the treated rats of both the age groups. The decrease in motor activity was greater following ethanol ingestion when compared with diazepam treatment and it was further augmented in combined administration of both drugs. Severe impairment was recorded in the senile rats when compared with the young groups. These results suggest that diazepam and ethanol produce motor debilities which are potentiated on combined drug treatment and also during senescence.

Original languageEnglish
Pages (from-to)141-148
Number of pages8
JournalBiomedical Letters
Volume60
Issue number236
StatePublished - 1 Dec 1999

Keywords

  • Aging
  • Diazepam
  • Ethanol
  • Locomotor activity
  • Spontaneous motor activity

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