Abstract
matrix presented The diastereoselective alkylation of glycolate oxazolidinones has been demonstrated as a method for the enantioselective preparation of α-alkoxy carboxylic acid derivatives and selectively protected 1,2-diols. Various protecting groups on the glycolate hydroxyl and multiple substitution patterns on allylic iodides are tolerated in the alkylation. Yields for the alkylations are typically 70-85% with diastereoselectivities of >98:2.
Original language | English |
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Pages (from-to) | 2165-2167 |
Number of pages | 3 |
Journal | Organic Letters |
Volume | 2 |
Issue number | 14 |
DOIs | |
State | Published - 13 Jul 2000 |