TY - JOUR
T1 - Diadenosine polyphosphates
T2 - Their biological and pharmacological significance
AU - Baxi, Mayur D.
AU - Vishwanatha, Jamboor K.
N1 - Funding Information:
This work was supported GM46459 to JKV.
PY - 1995/6
Y1 - 1995/6
N2 - Diadenosine polyphosphates are members of a group of dinucleoside polyphosphates that are ubiquitous in bacteria to mammals. In recent years, the diadenosine polyphosphates have received considerable attention in view of their multiple biological activities and potential pharmacological activities. Diadenosine polyphosphates have been identified as modulators of cardiovascular and neurotransmitter-like activities in recent years, besides their previously described role in cell proliferation and as signal molecules when cells are undergoing stress. Diadenosine polyphosphates and their synthetic analogues are being evaluated for their potential as pharmacological agents. This article discusses the various biological functions and physiological significance of the diadenosine polyphosphates.
AB - Diadenosine polyphosphates are members of a group of dinucleoside polyphosphates that are ubiquitous in bacteria to mammals. In recent years, the diadenosine polyphosphates have received considerable attention in view of their multiple biological activities and potential pharmacological activities. Diadenosine polyphosphates have been identified as modulators of cardiovascular and neurotransmitter-like activities in recent years, besides their previously described role in cell proliferation and as signal molecules when cells are undergoing stress. Diadenosine polyphosphates and their synthetic analogues are being evaluated for their potential as pharmacological agents. This article discusses the various biological functions and physiological significance of the diadenosine polyphosphates.
KW - ApA
KW - Diadenosine polyphosphate
KW - Dinucleoside polyphosphate
UR - http://www.scopus.com/inward/record.url?scp=0029044931&partnerID=8YFLogxK
U2 - 10.1016/1056-8719(94)00127-P
DO - 10.1016/1056-8719(94)00127-P
M3 - Review article
C2 - 7640391
AN - SCOPUS:0029044931
SN - 1056-8719
VL - 33
SP - 121
EP - 128
JO - Journal of Pharmacological and Toxicological Methods
JF - Journal of Pharmacological and Toxicological Methods
IS - 3
ER -