Diabetic keratopathy: Insights and challenges

S. Priyadarsini, A. Whelchel, S. Nicholas, R. Sharif, K. Riaz, D. Karamichos

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Ocular complications from diabetes mellitus are common. Diabetic keratopathy, the most frequent clinical condition affecting the human cornea, is a potentially sight-threatening condition caused mostly by epithelial disturbances that are of clinical and research attention because of their severity. Diabetic keratopathy exhibits several clinical manifestations, including persistent corneal epithelial erosion, superficial punctate keratopathy, delayed epithelial regeneration, and decreased corneal sensitivity, that may lead to compromised visual acuity or permanent vision loss. The limited amount of clinical studies makes it difficult to fully understand the pathobiology of diabetic keratopathy. Effective therapeutic approaches are elusive. We summarize the clinical manifestations of diabetic keratopathy and discuss available treatments and up-to-date research studies in an attempt to provide a thorough overview of the disorder.

Original languageEnglish
Pages (from-to)513-529
Number of pages17
JournalSurvey of Ophthalmology
Volume65
Issue number5
DOIs
StatePublished - 1 Sep 2020

Keywords

  • corneal diabetes
  • diabetes review
  • diabetic complications
  • diabetic keratopathy
  • gene therapy
  • metabolic disease
  • neurotrophic ulcer

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