Developmental validation of 15 X chromosomal short tandem repeat markers

Toni M. Diegoli, Adrian Linacre, Michael D. Coble

Research output: Contribution to journalArticle

Abstract

The use of X chromosomal short tandem repeat (STR) markers has been greatly increasing in the forensic setting. Using guidelines set forth previously for the validation of autosomal and Y STRs, aspects of the feasibility of routine X chromosomal STR use were evaluated. Two mini-X chromosomal STR multiplexes capable of amplifying 15 total markers were developed and utilized to determine allele nomenclature, allele/genotype frequencies, mutation rates, and linkage between markers. Additionally, a concordance study between these multiplexes and a commercially available kit was performed. Here, the authors present an overview of this extensive developmental validation study.

Original languageEnglish
Pages (from-to)e142-e143
JournalForensic Science International: Genetics Supplement Series
Volume4
Issue number1
DOIs
StatePublished - 30 Oct 2013

Keywords

  • Linkage
  • Multiplex development
  • Mutation rate
  • Population database
  • Short tandem repeat
  • X chromosome

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