Developmental Arsenic Exposure: Behavioral Dysfunctions and Neurochemical Perturbations

Riyaz Basha, G. Rajarami Reddy

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations


Arsenic is a metalloid that occurs naturally in the environment. From ancient times it has been popular as a homicidal and/or suicidal poison. Arsenic compounds are known to cause several health hazards; however, the developing brain seems to be most vulnerable. Arsenic causes psychomotor, verbal learning, and memory deficits in children. Laboratory studies investigated the mechanism of arsenic-induced neuronal and behavioral perturbations, which suggested the association of neurotransmitter systems and oxidative stress in arsenic-induced neurotoxic and behavioral effects. While the use of chelating agents in treating heavy metal toxicity is common, laboratory studies using metal chelators and anti-oxidants showed promising results suggesting this combination is an effective strategy for the retrieval of arsenic-induced toxicity. The supplementation of endogenous metals calcium and zinc along with monoisoamyl dimercaptosuccinic acid (MiADMSA), a thiol chelator, showed greater protective efficacy against arsenic-induced neurotoxicity and behavioral outcomes when compared to individual or any of the two agents.

Original languageEnglish
Title of host publicationHandbook of Arsenic Toxicology
PublisherElsevier Inc.
Number of pages15
ISBN (Electronic)9780124199552
ISBN (Print)9780124186880
StatePublished - 8 Jan 2015


  • Arsenic
  • Behavior
  • Development
  • Monoisoamyl dimercaptosuccinic acid
  • Neurotransmitters


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