Arsenic is a metalloid that occurs naturally in the environment. From ancient times it has been popular as a homicidal and/or suicidal poison. Arsenic compounds are known to cause several health hazards; however, the developing brain seems to be most vulnerable. Arsenic causes psychomotor, verbal learning, and memory deficits in children. Laboratory studies investigated the mechanism of arsenic-induced neuronal and behavioral perturbations, which suggested the association of neurotransmitter systems and oxidative stress in arsenic-induced neurotoxic and behavioral effects. While the use of chelating agents in treating heavy metal toxicity is common, laboratory studies using metal chelators and anti-oxidants showed promising results suggesting this combination is an effective strategy for the retrieval of arsenic-induced toxicity. The supplementation of endogenous metals calcium and zinc along with monoisoamyl dimercaptosuccinic acid (MiADMSA), a thiol chelator, showed greater protective efficacy against arsenic-induced neurotoxicity and behavioral outcomes when compared to individual or any of the two agents.
|Title of host publication||Handbook of Arsenic Toxicology|
|Number of pages||15|
|State||Published - 8 Jan 2015|
- Monoisoamyl dimercaptosuccinic acid