Abstract
Candida albicans and related species switch frequently and reversibly between a number of general phenotypes usually discriminated by colony morphology and in some cases by cellular morphology. Switching has been demonstrated to affect a number of physiologic and architectural characteristics of single cells including most of the putative virulence factors of C.albicans. In the past few years, we have cloned several genes regulated by switching in the white-opaque transition of C.albicans strain WO-1. Two of the genes, PEP1 and Op4, are transcribed only in the opaque phase, and one of the genes, Wh11, is transcribed only in the white phase. These coordinately regulated genes are unlinked in the genome and do not undergo sequence reorganization in switching. With the identification of a cis-acting regulatory sequence in the five-prime flanking sequence of Wh11, we now believe that phase-specific genes are regulated by transacting factors and that these factors may be coded for or under the direct regulation of a single master regulatory gene at which site the basic switch event occurs.
| Original language | English |
|---|---|
| Pages (from-to) | 194-201 |
| Number of pages | 8 |
| Journal | Oral Surgery, Oral Medicine, Oral Pathology |
| Volume | 78 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1 Jan 1994 |
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Developmental and molecular biology of switching in Candida albicans. / Soll, David R.; Morrow, Brian; Thyagarajan, Srikantha; Vargas, Kaaren; Wertz, Philip.
In: Oral Surgery, Oral Medicine, Oral Pathology, Vol. 78, No. 2, 01.01.1994, p. 194-201.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Developmental and molecular biology of switching in Candida albicans
AU - Soll, David R.
AU - Morrow, Brian
AU - Thyagarajan, Srikantha
AU - Vargas, Kaaren
AU - Wertz, Philip
PY - 1994/1/1
Y1 - 1994/1/1
N2 - Candida albicans and related species switch frequently and reversibly between a number of general phenotypes usually discriminated by colony morphology and in some cases by cellular morphology. Switching has been demonstrated to affect a number of physiologic and architectural characteristics of single cells including most of the putative virulence factors of C.albicans. In the past few years, we have cloned several genes regulated by switching in the white-opaque transition of C.albicans strain WO-1. Two of the genes, PEP1 and Op4, are transcribed only in the opaque phase, and one of the genes, Wh11, is transcribed only in the white phase. These coordinately regulated genes are unlinked in the genome and do not undergo sequence reorganization in switching. With the identification of a cis-acting regulatory sequence in the five-prime flanking sequence of Wh11, we now believe that phase-specific genes are regulated by transacting factors and that these factors may be coded for or under the direct regulation of a single master regulatory gene at which site the basic switch event occurs.
AB - Candida albicans and related species switch frequently and reversibly between a number of general phenotypes usually discriminated by colony morphology and in some cases by cellular morphology. Switching has been demonstrated to affect a number of physiologic and architectural characteristics of single cells including most of the putative virulence factors of C.albicans. In the past few years, we have cloned several genes regulated by switching in the white-opaque transition of C.albicans strain WO-1. Two of the genes, PEP1 and Op4, are transcribed only in the opaque phase, and one of the genes, Wh11, is transcribed only in the white phase. These coordinately regulated genes are unlinked in the genome and do not undergo sequence reorganization in switching. With the identification of a cis-acting regulatory sequence in the five-prime flanking sequence of Wh11, we now believe that phase-specific genes are regulated by transacting factors and that these factors may be coded for or under the direct regulation of a single master regulatory gene at which site the basic switch event occurs.
UR - http://www.scopus.com/inward/record.url?scp=0028487053&partnerID=8YFLogxK
U2 - 10.1016/0030-4220(94)90147-3
DO - 10.1016/0030-4220(94)90147-3
M3 - Article
VL - 78
SP - 194
EP - 201
JO - Oral Surgery, Oral Medicine, Oral Pathology
JF - Oral Surgery, Oral Medicine, Oral Pathology
SN - 0030-4220
IS - 2
ER -