Development of serotonin-mediated behavioral inhibition in the hyperthyroid mouse

Z. Michael Nagy, Michael J. Forster

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Experimental hyperthyroidism was induced in neonatal mice by thyroxine injections at 1-3 days of age. Control and thyroxine-treated mice were subsequently tested daily for locomotor activity following injections of methysergide, a serotonin antagonist, or saline from 10 through 15 days of age. Although thyroxine-treated mice were more active than controls, the ontogeny of methysergide-induced disinhibition of locomotor activity was similar for both thyroxine-treated and control mice. The results suggest that the early maturation of serotonim-mediated inhibition of behavioral arousal is not affected by thyroxine-accelerated development. Results are discussed in terms of the specificity of the pharmacological agent, methysergide.

Original languageEnglish
Pages (from-to)203-206
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume16
Issue number2
DOIs
StatePublished - 1 Jan 1982

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Hyperthyroidism
Thyroxine
Serotonin
Methysergide
Locomotion
Serotonin Antagonists
Injections
Arousal
Inhibition (Psychology)
Pharmacology

Keywords

  • Arousal
  • Locomotor activity
  • Methysergide
  • Neonatal mice
  • Serotonergic development
  • Thyroxine

Cite this

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Development of serotonin-mediated behavioral inhibition in the hyperthyroid mouse. / Michael Nagy, Z.; Forster, Michael J.

In: Pharmacology, Biochemistry and Behavior, Vol. 16, No. 2, 01.01.1982, p. 203-206.

Research output: Contribution to journalArticle

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