Abstract
Experimental hyperthyroidism was induced in neonatal mice by thyroxine injections at 1-3 days of age. Control and thyroxine-treated mice were subsequently tested daily for locomotor activity following injections of methysergide, a serotonin antagonist, or saline from 10 through 15 days of age. Although thyroxine-treated mice were more active than controls, the ontogeny of methysergide-induced disinhibition of locomotor activity was similar for both thyroxine-treated and control mice. The results suggest that the early maturation of serotonim-mediated inhibition of behavioral arousal is not affected by thyroxine-accelerated development. Results are discussed in terms of the specificity of the pharmacological agent, methysergide.
Original language | English |
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Pages (from-to) | 203-206 |
Number of pages | 4 |
Journal | Pharmacology, Biochemistry and Behavior |
Volume | 16 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1982 |
Keywords
- Arousal
- Locomotor activity
- Methysergide
- Neonatal mice
- Serotonergic development
- Thyroxine