Development of serotonin-mediated behavioral inhibition in the hyperthyroid mouse

Z. Michael Nagy, Michael J. Forster

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Experimental hyperthyroidism was induced in neonatal mice by thyroxine injections at 1-3 days of age. Control and thyroxine-treated mice were subsequently tested daily for locomotor activity following injections of methysergide, a serotonin antagonist, or saline from 10 through 15 days of age. Although thyroxine-treated mice were more active than controls, the ontogeny of methysergide-induced disinhibition of locomotor activity was similar for both thyroxine-treated and control mice. The results suggest that the early maturation of serotonim-mediated inhibition of behavioral arousal is not affected by thyroxine-accelerated development. Results are discussed in terms of the specificity of the pharmacological agent, methysergide.

Original languageEnglish
Pages (from-to)203-206
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume16
Issue number2
DOIs
StatePublished - Feb 1982

Keywords

  • Arousal
  • Locomotor activity
  • Methysergide
  • Neonatal mice
  • Serotonergic development
  • Thyroxine

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