Development and expansion of high-quality control region databases to improve forensic mtDNA evidence interpretation

Jodi A. Irwin, Jessica L. Saunier, Katharine M. Strouss, Kimberly A. Sturk, Toni M. Diegoli, Rebecca S. Just, Michael D. Coble, Walther Parson, Thomas J. Parsons

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

In an effort to increase the quantity, breadth and availability of mtDNA databases suitable for forensic comparisons, we have developed a high-throughput process to generate approximately 5000 control region sequences per year from regional US populations, global populations from which the current US population is derived and global populations currently under-represented in available forensic databases. The system utilizes robotic instrumentation for all laboratory steps from pre-extraction through sequence detection, and a rigorous eight-step, multi-laboratory data review process with entirely electronic data transfer. Over the past 3 years, nearly 10,000 control region sequences have been generated using this approach. These data are being made publicly available and should further address the need for consistent, high-quality mtDNA databases for forensic testing.

Original languageEnglish
Pages (from-to)154-157
Number of pages4
JournalForensic Science International: Genetics
Volume1
Issue number2
DOIs
StatePublished - 1 Jun 2007

Keywords

  • Control region
  • Mitochondrial DNA
  • Robotics
  • mtDNA databases

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    Irwin, J. A., Saunier, J. L., Strouss, K. M., Sturk, K. A., Diegoli, T. M., Just, R. S., Coble, M. D., Parson, W., & Parsons, T. J. (2007). Development and expansion of high-quality control region databases to improve forensic mtDNA evidence interpretation. Forensic Science International: Genetics, 1(2), 154-157. https://doi.org/10.1016/j.fsigen.2007.01.019