Abstract
Environmental metals are potentially toxic and can interfere with the metal-binding motifs of various critical proteins. This unit describes an electrophoretic method that can be used to measure the ability of a xenobiotic metal to bind a zinc-finger motif. Information gained using this protocol can lead to the identification of protein targets of metals and shed better light on their mechanisms of action.
Original language | English |
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Pages (from-to) | Unit12.11 |
Journal | Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.] |
Volume | Chapter 12 |
State | Published - Feb 2004 |