Determining the ability of xenobiotic metals to bind a specific protein domain by electrophoresis.

N. H. Zawia, Md Riyaz Basha, M. Razmiafshari

Research output: Contribution to journalArticle

Abstract

Environmental metals are potentially toxic and can interfere with the metal-binding motifs of various critical proteins. This unit describes an electrophoretic method that can be used to measure the ability of a xenobiotic metal to bind a zinc-finger motif. Information gained using this protocol can lead to the identification of protein targets of metals and shed better light on their mechanisms of action.

Original languageEnglish
Pages (from-to)Unit12.11
JournalCurrent protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.]
VolumeChapter 12
StatePublished - Feb 2004

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