Determining the ability of xenobiotic metals to bind a specific protein domain by electrophoresis.

N. H. Zawia; Md Riyaz Basha; M. Razmiafshari

Determining the ability of xenobiotic metals to bind a specific protein domain by electrophoresis.

N. H. Zawia, Md Riyaz Basha, M. Razmiafshari

Research output: Contribution to journal › Article › peer-review

Abstract

Environmental metals are potentially toxic and can interfere with the metal-binding motifs of various critical proteins. This unit describes an electrophoretic method that can be used to measure the ability of a xenobiotic metal to bind a zinc-finger motif. Information gained using this protocol can lead to the identification of protein targets of metals and shed better light on their mechanisms of action.

Original language	English
Pages (from-to)	Unit12.11
Journal	Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.]
Volume	Chapter 12
State	Published - Feb 2004

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title = "Determining the ability of xenobiotic metals to bind a specific protein domain by electrophoresis.",

abstract = "Environmental metals are potentially toxic and can interfere with the metal-binding motifs of various critical proteins. This unit describes an electrophoretic method that can be used to measure the ability of a xenobiotic metal to bind a zinc-finger motif. Information gained using this protocol can lead to the identification of protein targets of metals and shed better light on their mechanisms of action.",

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N2 - Environmental metals are potentially toxic and can interfere with the metal-binding motifs of various critical proteins. This unit describes an electrophoretic method that can be used to measure the ability of a xenobiotic metal to bind a zinc-finger motif. Information gained using this protocol can lead to the identification of protein targets of metals and shed better light on their mechanisms of action.

AB - Environmental metals are potentially toxic and can interfere with the metal-binding motifs of various critical proteins. This unit describes an electrophoretic method that can be used to measure the ability of a xenobiotic metal to bind a zinc-finger motif. Information gained using this protocol can lead to the identification of protein targets of metals and shed better light on their mechanisms of action.

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VL - Chapter 12

SP - Unit12.11

JO - Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.]

JF - Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.]

SN - 1934-9262

ER -

Determining the ability of xenobiotic metals to bind a specific protein domain by electrophoresis.

Abstract

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