Desorption Chemical Ionization, Thermospray, and Fast Atom Bombardment Mass Spectrometry of Dihydropyridine ⇋ Pyridinium Salt-Type Redox Systems

László Prókai; Bih Hsiung Hsu; Hassan Farag; Nicholas Bodor

doi:10.1021/ac00190a026

Desorption Chemical Ionization, Thermospray, and Fast Atom Bombardment Mass Spectrometry of Dihydropyridine ⇋ Pyridinium Salt-Type Redox Systems

László Prókai, Bih Hsiung Hsu, Hassan Farag, Nicholas Bodor

Research output: Contribution to journal › Article › peer-review

Abstract

Trigonellyi-substituted (pyridinium salt type) compounds decompose during sample introduction using desorption chemical ionization (DCI) and thermospray (TSP) ionization. Thermal dequaternization is the main degradation process in DCI, while hydrolytically sensitive bonds are subject to cleavage in the TSP source, and dequaternization and reduction to the dihydropyridine analogues are also observed. Fast atom bombardment (FAB) is the suggested method of Ionization because of its ability to provide an intense intact cation. The neutral dihydropyridine analogues can be effectively ionized by DCI and TSP. These methods are recommended, because bombardment-induced oxidation produces artifacts and shows a matrix effect in positive FAB.

Original language	English
Pages (from-to)	1723-1728
Number of pages	6
Journal	Analytical Chemistry
Volume	61
Issue number	15
DOIs	https://doi.org/10.1021/ac00190a026
State	Published - Aug 1989

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title = "Desorption Chemical Ionization, Thermospray, and Fast Atom Bombardment Mass Spectrometry of Dihydropyridine ⇋ Pyridinium Salt-Type Redox Systems",

abstract = "Trigonellyi-substituted (pyridinium salt type) compounds decompose during sample introduction using desorption chemical ionization (DCI) and thermospray (TSP) ionization. Thermal dequaternization is the main degradation process in DCI, while hydrolytically sensitive bonds are subject to cleavage in the TSP source, and dequaternization and reduction to the dihydropyridine analogues are also observed. Fast atom bombardment (FAB) is the suggested method of Ionization because of its ability to provide an intense intact cation. The neutral dihydropyridine analogues can be effectively ionized by DCI and TSP. These methods are recommended, because bombardment-induced oxidation produces artifacts and shows a matrix effect in positive FAB.",

author = "L{\'a}szl{\'o} Pr{\'o}kai and Hsu, {Bih Hsiung} and Hassan Farag and Nicholas Bodor",

year = "1989",

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T1 - Desorption Chemical Ionization, Thermospray, and Fast Atom Bombardment Mass Spectrometry of Dihydropyridine ⇋ Pyridinium Salt-Type Redox Systems

AU - Prókai, László

AU - Hsu, Bih Hsiung

AU - Farag, Hassan

AU - Bodor, Nicholas

PY - 1989/8

Y1 - 1989/8

N2 - Trigonellyi-substituted (pyridinium salt type) compounds decompose during sample introduction using desorption chemical ionization (DCI) and thermospray (TSP) ionization. Thermal dequaternization is the main degradation process in DCI, while hydrolytically sensitive bonds are subject to cleavage in the TSP source, and dequaternization and reduction to the dihydropyridine analogues are also observed. Fast atom bombardment (FAB) is the suggested method of Ionization because of its ability to provide an intense intact cation. The neutral dihydropyridine analogues can be effectively ionized by DCI and TSP. These methods are recommended, because bombardment-induced oxidation produces artifacts and shows a matrix effect in positive FAB.

AB - Trigonellyi-substituted (pyridinium salt type) compounds decompose during sample introduction using desorption chemical ionization (DCI) and thermospray (TSP) ionization. Thermal dequaternization is the main degradation process in DCI, while hydrolytically sensitive bonds are subject to cleavage in the TSP source, and dequaternization and reduction to the dihydropyridine analogues are also observed. Fast atom bombardment (FAB) is the suggested method of Ionization because of its ability to provide an intense intact cation. The neutral dihydropyridine analogues can be effectively ionized by DCI and TSP. These methods are recommended, because bombardment-induced oxidation produces artifacts and shows a matrix effect in positive FAB.

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Desorption Chemical Ionization, Thermospray, and Fast Atom Bombardment Mass Spectrometry of Dihydropyridine ⇋ Pyridinium Salt-Type Redox Systems

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