@article{9f3660850bf64c20b558252816cf8e3e,
title = "Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding",
abstract = "A series of thiophene PLK1 inhibitors was optimized for increased solubility and reduced protein binding through the appendage of basic amine functionality. Interesting selectivity between PLK1 and PLK3 was also obtained through these modifications.",
keywords = "Anti-mitotic, Cell cycle inhibitor, Polo-like kinase, Protein binding, Solubility, Thiophene",
author = "Emmitte, {Kyle A.} and Adjebang, {George M.} and Andrews, {C. Webb} and Alberti, {Jennifer G.Badiang} and Ramesh Bambal and Chamberlain, {Stanley D.} and Davis-Ward, {Ronda G.} and Dickson, {Hamilton D.} and Hassler, {Daniel F.} and Hornberger, {Keith R.} and Jackson, {Jeffrey R.} and Kuntz, {Kevin W.} and Lansing, {Timothy J.} and Mook, {Robert A.} and Nailor, {Kristen E.} and Pobanz, {Mark A.} and Smith, {Stephon C.} and Sung, {Chiu Mei} and Mui Cheung",
year = "2009",
month = mar,
day = "15",
doi = "10.1016/j.bmcl.2009.01.094",
language = "English",
volume = "19",
pages = "1694--1697",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Ltd",
number = "6",
}