Design and Synthesis of Conformationally Flexible Scaffold as Bitopic Ligands for Potent D₃-Selective Antagonists

Keyphrases

• D3 Receptor 100%
• Selective Antagonist 100%
• Bitopic Ligands 100%
• Flexible Scaffolds 100%
• Dopamine 40%
• Benzamide 40%
• High Potency 40%
• D3 Receptor Antagonist 40%
• Secondary Binding Site 40%
• Subtype Selectivity 20%
• Receptor Affinity 20%
• Binding Affinity 20%
• IC50 20%
• Pyridine 20%
• D2 Receptor 20%
• Minimal Impact 20%
• 5-HT3 Receptor 20%
• Behavioral Pharmacology 20%
• Arrestin Recruitment 20%
• PET Radiotracers 20%
• Carboxamide 20%
• Radiotracer Development 20%
• Computational Study 20%
• Binding Fragment 20%
• Aryl 20%
• Pharmacology Studies 20%
• SAR Study 20%
• Metoclopramide 20%
• Endogenous Dopamine 20%
• Alternative Scaffold 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Receptor 100%
• Binding Site 33%
• Receptor Antagonist 33%
• Benzamide 33%
• G Protein Coupled Receptor 16%
• IC50 16%
• Structure Activity Relationship 16%
• Behavioral Pharmacology 16%
• Tracer 16%
• Carboxamide 16%
• Serotonin 3 Receptor 16%
• Lead Compound 16%
• Retina S Antigen 16%
• Metoclopramide 16%
• Polyethylene Terephthalate 16%