Design and exploratory neuropharmacological evaluation of novel thyrotropin-releasing hormone analogs and their brain-targeting bioprecursor prodrugs

Keyphrases

• Thyrotropin 100%
• Bioprecursor Prodrug 100%
• Brain Targeting 100%
• Neuropharmacological 100%
• Antidepressants 20%
• Central Nervous System 20%
• Mouse Brain 20%
• Systemic Administration 20%
• Model-based Testing 20%
• Amino 20%
• Stable Analogue 20%
• Metabolic Stability 20%
• Pyridinium 20%
• Response Characteristics 20%
• Analeptic 20%
• Cholinergic Effects 20%
• Metabolically Stable 20%

Neuroscience

• Prodrug 100%
• Thyrotropin-Releasing Hormone 100%
• Protirelin Derivative 100%
• Central Nervous System 33%
• Antidepressant 33%
• Amino Terminal Sequence 33%
• Cholinergic 33%
• Mouse Brain 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Prodrug 100%
• Protirelin 100%
• Protirelin Derivative 100%
• Antidepressant 33%
• Bioavailability 33%
• Cholinergic Receptor Stimulating Agent 33%
• Systemic Administration 33%