Depressed basal hypothalamic neuronal activity in type-1 diabetic mice is correlated with proinflammatory secretion of HMBG1

Keyphrases

• Neuronal Activity 100%
• Diabetic Mice 100%
• Type 1 Diabetic 100%
• High Mobility Group Box 1 (HMGB1) 100%
• Nuclear Localization 40%
• Streptozotocin 40%
• Ins2Akita Mouse 40%
• Neuroinflammation 20%
• Diabetes 20%
• Diabetic 20%
• Growth Factors 20%
• Immunohistochemistry 20%
• Insulin-like Growth factor-1 20%
• Neurodegeneration 20%
• Confocal Microscopy 20%
• Inflammatory State 20%
• Paraventricular nucleus of the Hypothalamus 20%
• Type 1 Diabetes Mellitus (T1DM) 20%
• Insulin-like 20%
• Genetic Model 20%
• Inflammatory Mediators 20%
• Neuroprotective Factors 20%
• Type I Diabetes 20%
• Inflammatory Process 20%
• Diabetic Animals 20%
• Thalamic 20%
• MEMRI 20%
• Ins2Akita 20%
• Insulin-like Growth Factor Binding Protein (IGFBP) 20%
• Insulin-like Growth Factor Binding protein-3 (IGFBP-3) 20%
• Nuclear Releases 20%
• Hypothalamic Inflammation 20%

Neuroscience

• Diabetes Mellitus 100%
• Neuronal Activity 100%
• High-Mobility Group 100%
• Streptozotocin 40%
• Neuroprotective Agent 20%
• Protein Binding 20%
• Immunohistochemistry 20%
• Neurodegeneration 20%
• Confocal Microscopy 20%
• Hypothalamus 20%
• Magnetic Resonance Imaging 20%
• Somatomedin 20%