TY - JOUR
T1 - Decrease in high density lipoprotein cholesterol (HDL-C) levels following gemfibrozil therapy
AU - Lacko, Andras G.
AU - Kudchodkar, Bhalchandra J.
AU - Loney, Wayne W.
AU - Clearfield, Michael B.
AU - Weis, Stephen
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1998
Y1 - 1998
N2 - This report represents the continuation of our studies on the effects of gemfibrozil therapy on high density lipoprotein cholesterol levels. Previously, we reported that despite an impressive mean increase in high density lipoprotein cholesterol (20%), the response to 12 weeks of gemfibrozil therapy was highly variable. Accordingly, out of the 27 subjects studied, five actually had lower high density lipoprotein cholesterol at the conclusion of therapy compared to baseline values. The changes observed in plasma lipids, combined with correlational relationships suggest that the conversion of triglyceride rich lipoprotein components into high density lipoprotein may be impaired in those subjects that respond poorly or negatively to gemfibrozil therapy.
AB - This report represents the continuation of our studies on the effects of gemfibrozil therapy on high density lipoprotein cholesterol levels. Previously, we reported that despite an impressive mean increase in high density lipoprotein cholesterol (20%), the response to 12 weeks of gemfibrozil therapy was highly variable. Accordingly, out of the 27 subjects studied, five actually had lower high density lipoprotein cholesterol at the conclusion of therapy compared to baseline values. The changes observed in plasma lipids, combined with correlational relationships suggest that the conversion of triglyceride rich lipoprotein components into high density lipoprotein may be impaired in those subjects that respond poorly or negatively to gemfibrozil therapy.
KW - Gemfibrozil therapy
KW - High density lipoprotein cholesterol
KW - Triglycerides
UR - http://www.scopus.com/inward/record.url?scp=0031848816&partnerID=8YFLogxK
U2 - 10.1515/CCLM.1998.066
DO - 10.1515/CCLM.1998.066
M3 - Article
C2 - 9711427
AN - SCOPUS:0031848816
SN - 1434-6621
VL - 36
SP - 389
EP - 392
JO - Clinical Chemistry and Laboratory Medicine
JF - Clinical Chemistry and Laboratory Medicine
IS - 6
ER -