DAV131A Protects Hamsters from Lethal Clostridioides difficile Infection Induced by Fluoroquinolones

Nathalie Saint-Lu, Charles Burdet, Frédérique Sablier-Gallis, Tanguy Corbel, Agathe Nevière, Sakina Sayah-Jeanne, Mark Pulse, William Weiss, Stéphanie Ferreira, Antoine Andremont, France Mentré, Jean de Gunzburg

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Abstract

Fluoroquinolone treatments induce dysbiosis of the intestinal microbiota, resulting in loss of resistance to colonization by exogenous bacteria such as Clostridioides difficile that may cause severe diarrhea in humans and lethal infection in hamsters. We show here that DAV131A, a charcoal-based adsorbent, decreases the intestinal levels of the fluoroquinolone antibiotics levofloxacin and ciprofloxacin in hamsters, protects their intestinal microbiota, and prevents lethal infection by C. difficile.

Original languageEnglish
Article numbere01196-19
JournalAntimicrobial agents and chemotherapy
Volume64
Issue number1
DOIs
StatePublished - 2020

Keywords

  • Antibiotics
  • Clostridioides difficile infection
  • Dysbiosis
  • Fluoroquinolones
  • Hamster animal model
  • Prevention

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    Saint-Lu, N., Burdet, C., Sablier-Gallis, F., Corbel, T., Nevière, A., Sayah-Jeanne, S., Pulse, M., Weiss, W., Ferreira, S., Andremont, A., Mentré, F., & de Gunzburg, J. (2020). DAV131A Protects Hamsters from Lethal Clostridioides difficile Infection Induced by Fluoroquinolones. Antimicrobial agents and chemotherapy, 64(1), [e01196-19]. https://doi.org/10.1128/AAC.01196-19