DAV131A Protects Hamsters from Lethal Clostridioides difficile Infection Induced by Fluoroquinolones

Nathalie Saint-Lu, Charles Burdet, Frédérique Sablier-Gallis, Tanguy Corbel, Agathe Nevière, Sakina Sayah-Jeanne, Mark Pulse, William Weiss, Stéphanie Ferreira, Antoine Andremont, France Mentré, Jean de Gunzburg

Research output: Contribution to journalArticle

Abstract

Fluoroquinolone treatments induce dysbiosis of the intestinal microbiota, resulting in loss of resistance to colonization by exogenous bacteria such as Clostridioides difficile that may cause severe diarrhea in humans and lethal infection in hamsters. We show here that DAV131A, a charcoal-based adsorbent, decreases the intestinal levels of the fluoroquinolone antibiotics levofloxacin and ciprofloxacin in hamsters, protects their intestinal microbiota, and prevents lethal infection by C. difficile.

Original languageEnglish
Article numbere01196-19
JournalAntimicrobial agents and chemotherapy
Volume64
Issue number1
DOIs
StatePublished - 1 Jan 2020

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Fluoroquinolones
Cricetinae
Dysbiosis
Levofloxacin
Charcoal
Ciprofloxacin
Infection
Diarrhea
Anti-Bacterial Agents
Bacteria
Gastrointestinal Microbiome

Keywords

  • Antibiotics
  • Clostridioides difficile infection
  • Dysbiosis
  • Fluoroquinolones
  • Hamster animal model
  • Prevention

Cite this

Saint-Lu, N., Burdet, C., Sablier-Gallis, F., Corbel, T., Nevière, A., Sayah-Jeanne, S., ... de Gunzburg, J. (2020). DAV131A Protects Hamsters from Lethal Clostridioides difficile Infection Induced by Fluoroquinolones. Antimicrobial agents and chemotherapy, 64(1), [e01196-19]. https://doi.org/10.1128/AAC.01196-19
Saint-Lu, Nathalie ; Burdet, Charles ; Sablier-Gallis, Frédérique ; Corbel, Tanguy ; Nevière, Agathe ; Sayah-Jeanne, Sakina ; Pulse, Mark ; Weiss, William ; Ferreira, Stéphanie ; Andremont, Antoine ; Mentré, France ; de Gunzburg, Jean. / DAV131A Protects Hamsters from Lethal Clostridioides difficile Infection Induced by Fluoroquinolones. In: Antimicrobial agents and chemotherapy. 2020 ; Vol. 64, No. 1.
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Saint-Lu, N, Burdet, C, Sablier-Gallis, F, Corbel, T, Nevière, A, Sayah-Jeanne, S, Pulse, M, Weiss, W, Ferreira, S, Andremont, A, Mentré, F & de Gunzburg, J 2020, 'DAV131A Protects Hamsters from Lethal Clostridioides difficile Infection Induced by Fluoroquinolones', Antimicrobial agents and chemotherapy, vol. 64, no. 1, e01196-19. https://doi.org/10.1128/AAC.01196-19

DAV131A Protects Hamsters from Lethal Clostridioides difficile Infection Induced by Fluoroquinolones. / Saint-Lu, Nathalie; Burdet, Charles; Sablier-Gallis, Frédérique; Corbel, Tanguy; Nevière, Agathe; Sayah-Jeanne, Sakina; Pulse, Mark; Weiss, William; Ferreira, Stéphanie; Andremont, Antoine; Mentré, France; de Gunzburg, Jean.

In: Antimicrobial agents and chemotherapy, Vol. 64, No. 1, e01196-19, 01.01.2020.

Research output: Contribution to journalArticle

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T1 - DAV131A Protects Hamsters from Lethal Clostridioides difficile Infection Induced by Fluoroquinolones

AU - Saint-Lu, Nathalie

AU - Burdet, Charles

AU - Sablier-Gallis, Frédérique

AU - Corbel, Tanguy

AU - Nevière, Agathe

AU - Sayah-Jeanne, Sakina

AU - Pulse, Mark

AU - Weiss, William

AU - Ferreira, Stéphanie

AU - Andremont, Antoine

AU - Mentré, France

AU - de Gunzburg, Jean

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AB - Fluoroquinolone treatments induce dysbiosis of the intestinal microbiota, resulting in loss of resistance to colonization by exogenous bacteria such as Clostridioides difficile that may cause severe diarrhea in humans and lethal infection in hamsters. We show here that DAV131A, a charcoal-based adsorbent, decreases the intestinal levels of the fluoroquinolone antibiotics levofloxacin and ciprofloxacin in hamsters, protects their intestinal microbiota, and prevents lethal infection by C. difficile.

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KW - Clostridioides difficile infection

KW - Dysbiosis

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Saint-Lu N, Burdet C, Sablier-Gallis F, Corbel T, Nevière A, Sayah-Jeanne S et al. DAV131A Protects Hamsters from Lethal Clostridioides difficile Infection Induced by Fluoroquinolones. Antimicrobial agents and chemotherapy. 2020 Jan 1;64(1). e01196-19. https://doi.org/10.1128/AAC.01196-19