TY - JOUR
T1 - DAV131A Protects Hamsters from Lethal Clostridioides difficile Infection Induced by Fluoroquinolones
AU - Saint-Lu, Nathalie
AU - Burdet, Charles
AU - Sablier-Gallis, Frédérique
AU - Corbel, Tanguy
AU - Nevière, Agathe
AU - Sayah-Jeanne, Sakina
AU - Pulse, Mark
AU - Weiss, William
AU - Ferreira, Stéphanie
AU - Andremont, Antoine
AU - Mentré, France
AU - de Gunzburg, Jean
N1 - Funding Information:
N.S.-L., F.S.-G., S.S.-J., A.A., F.M., and J.D.G. designed the research. N.S.-L., T.C., M.P., and W.W. performed the research. S.F., T.C., and A.N. performed the metagenomic analysis. A.N. performed the statistical analysis of the data. J.D.G., A.A., C.B., F.M., T.C., and N.S.-L. wrote the paper. All authors agreed on the final version of the manuscript. N.S.-L., F.S.-G., T.C., A.N., and S.S.-J. are employees of the Da Volterra Company. C.B., A.A., F.M., and J.D.G. are consultants for the Da Volterra Company. This study was supported by Da Volterra, Paris, France.
Publisher Copyright:
© 2019 American Society for Microbiology. All Rights Reserved.
PY - 2020
Y1 - 2020
N2 - Fluoroquinolone treatments induce dysbiosis of the intestinal microbiota, resulting in loss of resistance to colonization by exogenous bacteria such as Clostridioides difficile that may cause severe diarrhea in humans and lethal infection in hamsters. We show here that DAV131A, a charcoal-based adsorbent, decreases the intestinal levels of the fluoroquinolone antibiotics levofloxacin and ciprofloxacin in hamsters, protects their intestinal microbiota, and prevents lethal infection by C. difficile.
AB - Fluoroquinolone treatments induce dysbiosis of the intestinal microbiota, resulting in loss of resistance to colonization by exogenous bacteria such as Clostridioides difficile that may cause severe diarrhea in humans and lethal infection in hamsters. We show here that DAV131A, a charcoal-based adsorbent, decreases the intestinal levels of the fluoroquinolone antibiotics levofloxacin and ciprofloxacin in hamsters, protects their intestinal microbiota, and prevents lethal infection by C. difficile.
KW - Antibiotics
KW - Clostridioides difficile infection
KW - Dysbiosis
KW - Fluoroquinolones
KW - Hamster animal model
KW - Prevention
UR - http://www.scopus.com/inward/record.url?scp=85077016803&partnerID=8YFLogxK
U2 - 10.1128/AAC.01196-19
DO - 10.1128/AAC.01196-19
M3 - Article
C2 - 31636067
AN - SCOPUS:85077016803
SN - 0066-4804
VL - 64
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 1
M1 - e01196-19
ER -