Cyclic nucleotide-gated cation channel expression in embryonic chick brain

Leslie C. Timpe; Kun Lin Jin; Luis Puelles; John L.R. Rubenstein

doi:10.1016/S0169-328X(99)00018-2

Cyclic nucleotide-gated cation channel expression in embryonic chick brain

Leslie C. Timpe, Kun Lin Jin, Luis Puelles, John L.R. Rubenstein

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Cyclic nucleotide-gated cation channels mediate sensory transduction in vertebrate photoreceptors and olfactory epithelium. These channels are also present in some non-sensory cells, but little is known of their physiOlOgiCal roles outside sensory systems. Using in situ hybridization we found that cyclic nucleotide channel mRNA is expressed specifically in the embryonic chicken forebrain, thalamus, optic tectum, basal midbrain and hindbrain, as well as in the branchial arches, limb buds and skin. Cyclic nucleotide gated channels may thus contribute to development or to cellular differentiation in the brain and in other tissues.

Original language	English
Pages (from-to)	175-178
Number of pages	4
Journal	Molecular Brain Research
Volume	66
Issue number	1-2
DOIs	https://doi.org/10.1016/S0169-328X(99)00018-2
State	Published - 20 Mar 1999

Keywords

CNG channel
Chicken
Cyclic nucleotide-activated ion channel

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10.1016/S0169-328X(99)00018-2

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title = "Cyclic nucleotide-gated cation channel expression in embryonic chick brain",

abstract = "Cyclic nucleotide-gated cation channels mediate sensory transduction in vertebrate photoreceptors and olfactory epithelium. These channels are also present in some non-sensory cells, but little is known of their physiOlOgiCal roles outside sensory systems. Using in situ hybridization we found that cyclic nucleotide channel mRNA is expressed specifically in the embryonic chicken forebrain, thalamus, optic tectum, basal midbrain and hindbrain, as well as in the branchial arches, limb buds and skin. Cyclic nucleotide gated channels may thus contribute to development or to cellular differentiation in the brain and in other tissues.",

keywords = "CNG channel, Chicken, Cyclic nucleotide-activated ion channel",

author = "Timpe, {Leslie C.} and Jin, {Kun Lin} and Luis Puelles and Rubenstein, {John L.R.}",

note = "Funding Information: We thank Brian Williams, PhD, for his advice and Ms. Katherine A. Logee for technical support. This work was supported by NIH Grant PO1 HL43821 and the Dept. of Veterans Affairs.",

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T1 - Cyclic nucleotide-gated cation channel expression in embryonic chick brain

AU - Timpe, Leslie C.

AU - Jin, Kun Lin

AU - Puelles, Luis

AU - Rubenstein, John L.R.

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N2 - Cyclic nucleotide-gated cation channels mediate sensory transduction in vertebrate photoreceptors and olfactory epithelium. These channels are also present in some non-sensory cells, but little is known of their physiOlOgiCal roles outside sensory systems. Using in situ hybridization we found that cyclic nucleotide channel mRNA is expressed specifically in the embryonic chicken forebrain, thalamus, optic tectum, basal midbrain and hindbrain, as well as in the branchial arches, limb buds and skin. Cyclic nucleotide gated channels may thus contribute to development or to cellular differentiation in the brain and in other tissues.

AB - Cyclic nucleotide-gated cation channels mediate sensory transduction in vertebrate photoreceptors and olfactory epithelium. These channels are also present in some non-sensory cells, but little is known of their physiOlOgiCal roles outside sensory systems. Using in situ hybridization we found that cyclic nucleotide channel mRNA is expressed specifically in the embryonic chicken forebrain, thalamus, optic tectum, basal midbrain and hindbrain, as well as in the branchial arches, limb buds and skin. Cyclic nucleotide gated channels may thus contribute to development or to cellular differentiation in the brain and in other tissues.

KW - CNG channel

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KW - Cyclic nucleotide-activated ion channel

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Cyclic nucleotide-gated cation channel expression in embryonic chick brain

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