Cyclic AMP response element binding protein (CREB) and CREB binding protein (CBP) in global cerebral ischemia

Kunlin Jin; Xiao Ou Mao; Roger P. Simon; David A. Greenberg

doi:10.1385/JMN:16:1:49

Cyclic AMP response element binding protein (CREB) and CREB binding protein (CBP) in global cerebral ischemia

Kunlin Jin, Xiao Ou Mao, Roger P. Simon, David A. Greenberg

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Cyclic AMP (cAMP) response element binding protein (CREB) is a transcription factor that has been implicated in neuronal responses to ischemia. We examined the effect of global cerebral ischemia in the rat on the expression of CREB, its transcriptionally active phosphorylated form (pCREB), and the nuclear adaptor protein, CREB binding protein (CBP). Global ischemia induced the expression of pCREB and CBP in vulnerable neurons of the hippocampal CA1 sector. In primary cultures of murine cortical neurons subjected to hypoxia, CBP was selectively expressed in cells with morphologically intact cell nuclei, and not in cells with condensed or fragmented nuclei indicative of irreversibly damaged neurons. These results support a role for transcriptional activation by CREB and CBP in neuronal cell-survival programs following cerebral ischemia.

Original language	English
Pages (from-to)	49-56
Number of pages	8
Journal	Journal of Molecular Neuroscience
Volume	16
Issue number	1
DOIs	https://doi.org/10.1385/JMN:16:1:49
State	Published - 2001

Keywords

CREB binding protein (CBP)
Cell death
Cerebralischemia
Cyclic AMP response element binding protein (CREB)
Transcription factor

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title = "Cyclic AMP response element binding protein (CREB) and CREB binding protein (CBP) in global cerebral ischemia",

abstract = "Cyclic AMP (cAMP) response element binding protein (CREB) is a transcription factor that has been implicated in neuronal responses to ischemia. We examined the effect of global cerebral ischemia in the rat on the expression of CREB, its transcriptionally active phosphorylated form (pCREB), and the nuclear adaptor protein, CREB binding protein (CBP). Global ischemia induced the expression of pCREB and CBP in vulnerable neurons of the hippocampal CA1 sector. In primary cultures of murine cortical neurons subjected to hypoxia, CBP was selectively expressed in cells with morphologically intact cell nuclei, and not in cells with condensed or fragmented nuclei indicative of irreversibly damaged neurons. These results support a role for transcriptional activation by CREB and CBP in neuronal cell-survival programs following cerebral ischemia.",

keywords = "CREB binding protein (CBP), Cell death, Cerebralischemia, Cyclic AMP response element binding protein (CREB), Transcription factor",

author = "Kunlin Jin and Mao, {Xiao Ou} and Simon, {Roger P.} and Greenberg, {David A.}",

note = "Funding Information: Supported by USPHS grants NS35965 and NS37695.",

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AU - Mao, Xiao Ou

AU - Simon, Roger P.

AU - Greenberg, David A.

N1 - Funding Information: Supported by USPHS grants NS35965 and NS37695.

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AB - Cyclic AMP (cAMP) response element binding protein (CREB) is a transcription factor that has been implicated in neuronal responses to ischemia. We examined the effect of global cerebral ischemia in the rat on the expression of CREB, its transcriptionally active phosphorylated form (pCREB), and the nuclear adaptor protein, CREB binding protein (CBP). Global ischemia induced the expression of pCREB and CBP in vulnerable neurons of the hippocampal CA1 sector. In primary cultures of murine cortical neurons subjected to hypoxia, CBP was selectively expressed in cells with morphologically intact cell nuclei, and not in cells with condensed or fragmented nuclei indicative of irreversibly damaged neurons. These results support a role for transcriptional activation by CREB and CBP in neuronal cell-survival programs following cerebral ischemia.

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Cyclic AMP response element binding protein (CREB) and CREB binding protein (CBP) in global cerebral ischemia

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