Cyclic AMP response element binding protein (CREB) and CREB binding protein (CBP) in global cerebral ischemia

Kunlin Jin, Xiao Ou Mao, Roger P. Simon, David A. Greenberg

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Cyclic AMP (cAMP) response element binding protein (CREB) is a transcription factor that has been implicated in neuronal responses to ischemia. We examined the effect of global cerebral ischemia in the rat on the expression of CREB, its transcriptionally active phosphorylated form (pCREB), and the nuclear adaptor protein, CREB binding protein (CBP). Global ischemia induced the expression of pCREB and CBP in vulnerable neurons of the hippocampal CA1 sector. In primary cultures of murine cortical neurons subjected to hypoxia, CBP was selectively expressed in cells with morphologically intact cell nuclei, and not in cells with condensed or fragmented nuclei indicative of irreversibly damaged neurons. These results support a role for transcriptional activation by CREB and CBP in neuronal cell-survival programs following cerebral ischemia.

Original languageEnglish
Pages (from-to)49-56
Number of pages8
JournalJournal of Molecular Neuroscience
Volume16
Issue number1
DOIs
StatePublished - 2001

Keywords

  • CREB binding protein (CBP)
  • Cell death
  • Cerebralischemia
  • Cyclic AMP response element binding protein (CREB)
  • Transcription factor

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