@article{0aebd99cc9e343e88ac5252fa9bb72f4,
title = "Current status of gene therapy strategies to treat HIV/AIDS",
abstract = "Progress in developing effective gene transfer approaches to treat HIV-1 infection has been steady. Many different transgenes have been reported to inhibit HIV-1 in vitro. However, effective translation of such results to clinical practice, or even to animal models of AIDS, has been challenging. Among the reasons for this failure are uncertainty as to the most effective cell population(s) to target, the diffuseness of these target cells in the body, and ineffective or insufficiently durable gene delivery. Better understanding of the HIV-1 replicative cycle, host factors involved in HIV-1 infection, vector biology and application, transgene technology, animal models, and clinical study design have all contributed vastly to planning current and future strategies for application of gene therapeutic approaches to the treatment of AIDS. This review focuses on the newest developments in these areas and provides a strong basis for renewed optimism that gene therapy will have an important role to play in treating people infected with HIV-1.",
keywords = "AIDS, Cellular cofactors, Gene therapy, Transduction, Viral vectors",
author = "Strayer, {David S.} and Ramesh Akkina and Bunnell, {Bruce A.} and Boro Dropulic and Vicente Planelles and Pomerantz, {Roger J.} and Rossi, {John J.} and Zaia, {John A.}",
note = "Funding Information: The authors thank many at NIH for their interest in and encouragement of our research, especially Drs. Sandra Bridges, Scott Cairns, Kathy Kopnisky, Diane Rausch, and Frosso Voulgaropoulou for their continuing efforts in nurturing gene therapy studies for HIV/AIDS. We are particularly indebted to the late Dr. Nava Sarver for her enthusiastic support. Our many colleagues are gratefully acknowledged: by dint of their past and continuing accomplishments, the field of AIDS gene therapy exists and grows. Despite our best efforts to provide an up-to-date summary of HIV-1-directed gene therapy, published works in this field are far too numerous to have all been included. We sincerely apologize for any omissions. We also thank our many collaborators and lab members, too numerous to name, whose efforts, energy, and ideas are responsible for much of the work accomplished in our respective laboratories. Dr. Gwendolyn Binder and Ms. Marie Acevedo helped compile the manuscript. Support for research described here included NIH Grants AI29329, AI41399, AI42552, AI48244, AI49057, AI054188, AI50492, AI54907, AI061839, HL074704, MH70287, and RR00043. ",
year = "2005",
month = jun,
doi = "10.1016/j.ymthe.2005.01.020",
language = "English",
volume = "11",
pages = "823--842",
journal = "Molecular Therapy",
issn = "1525-0016",
publisher = "Cell Press",
number = "6",
}