Current status of gene therapy strategies to treat HIV/AIDS

David S. Strayer, Ramesh Akkina, Bruce A. Bunnell, Boro Dropulic, Vicente Planelles, Roger J. Pomerantz, John J. Rossi, John A. Zaia

Research output: Contribution to journalReview article

81 Scopus citations

Abstract

Progress in developing effective gene transfer approaches to treat HIV-1 infection has been steady. Many different transgenes have been reported to inhibit HIV-1 in vitro. However, effective translation of such results to clinical practice, or even to animal models of AIDS, has been challenging. Among the reasons for this failure are uncertainty as to the most effective cell population(s) to target, the diffuseness of these target cells in the body, and ineffective or insufficiently durable gene delivery. Better understanding of the HIV-1 replicative cycle, host factors involved in HIV-1 infection, vector biology and application, transgene technology, animal models, and clinical study design have all contributed vastly to planning current and future strategies for application of gene therapeutic approaches to the treatment of AIDS. This review focuses on the newest developments in these areas and provides a strong basis for renewed optimism that gene therapy will have an important role to play in treating people infected with HIV-1.

Original languageEnglish
Pages (from-to)823-842
Number of pages20
JournalMolecular Therapy
Volume11
Issue number6
DOIs
StatePublished - Jun 2005

Keywords

  • AIDS
  • Cellular cofactors
  • Gene therapy
  • Transduction
  • Viral vectors

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    Strayer, D. S., Akkina, R., Bunnell, B. A., Dropulic, B., Planelles, V., Pomerantz, R. J., Rossi, J. J., & Zaia, J. A. (2005). Current status of gene therapy strategies to treat HIV/AIDS. Molecular Therapy, 11(6), 823-842. https://doi.org/10.1016/j.ymthe.2005.01.020