TY - JOUR
T1 - Current perspectives in immunotherapy for liver cancer
AU - Lambring, Christoffer Briggs
AU - Ghabach, Bassam
AU - Narra, Kalyani
AU - Basha, Riyaz
PY - 2020
Y1 - 2020
N2 - Liver cancer is a particularly aggressive group of malignancies with historically low survival rates. Despite advancements in cancer treatments in general in the last few decades, incidence and mortality have not changed. Even though some phase 1 and 2 studies have shown promising results, many medication have failed to reach a sustainable level of efficacy to move into the clinical setting. Immunotherapy drugs have shown impressive results in the treatment of specific immunogenic cancers, prompting the possibility of their use in liver cancers. Immunotherapy medications approved for other cancers have received FDA accelerated approval for treatment of hepatocellular carcinoma. But, these approvals are contingent upon verification and description of clinical benefit in confirmatory trials. With more treatments in development involving cancer vaccines and natural killer cell–mediated therapy, liver cancer treatment is being reinvigorated with a broad array of new treatment angles. In this review article, we discuss these treatments, focusing on mechanism of action and clinical trials. Much needed advancements in treating late-and early-stage liver cancers will require new and innovative immunotherapeutic treatments.
AB - Liver cancer is a particularly aggressive group of malignancies with historically low survival rates. Despite advancements in cancer treatments in general in the last few decades, incidence and mortality have not changed. Even though some phase 1 and 2 studies have shown promising results, many medication have failed to reach a sustainable level of efficacy to move into the clinical setting. Immunotherapy drugs have shown impressive results in the treatment of specific immunogenic cancers, prompting the possibility of their use in liver cancers. Immunotherapy medications approved for other cancers have received FDA accelerated approval for treatment of hepatocellular carcinoma. But, these approvals are contingent upon verification and description of clinical benefit in confirmatory trials. With more treatments in development involving cancer vaccines and natural killer cell–mediated therapy, liver cancer treatment is being reinvigorated with a broad array of new treatment angles. In this review article, we discuss these treatments, focusing on mechanism of action and clinical trials. Much needed advancements in treating late-and early-stage liver cancers will require new and innovative immunotherapeutic treatments.
KW - Durvalumab
KW - Hepatocellular carcinoma
KW - Immunotherapy
KW - Ipilimumab
KW - Liver cancer
KW - Nivolumab
UR - http://www.scopus.com/inward/record.url?scp=85090103136&partnerID=8YFLogxK
U2 - 10.1615/critrevoncog.2020034965
DO - 10.1615/critrevoncog.2020034965
M3 - Article
C2 - 32865909
AN - SCOPUS:85090103136
VL - 25
SP - 31
EP - 46
JO - Critical Reviews in Oncogenesis
JF - Critical Reviews in Oncogenesis
SN - 0893-9675
IS - 1
ER -