Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB

Rui Wang; Ying Bo Li; Yu Hua Li; Ying Xu; Hong li Wu; Xue Jun Li

doi:10.1016/j.brainres.2008.01.104

Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB

Rui Wang, Ying Bo Li, Yu Hua Li, Ying Xu, Hong li Wu, Xue Jun Li

Research output: Contribution to journal › Article › peer-review

109 Scopus citations

Abstract

Curcumin is a major active component isolated from Curcuma longa. Previously, we have reported its significant antidepressant effect. However, the mechanisms underlying the antidepressant effects are still obscure. In the present study, we explored the effect of curcumin against glutamate excitotoxicity, mainly focusing on the neuroprotective effects of curcumin on the expression of Brain-Derived Neurotrophic Factor (BDNF), which is deeply involved in the etiology and treatment of depression. Exposure of rat cortical neurons to 10 μM glutamate for 24 h caused a significant decrease in BDNF level, accompanied with reduced cell viability and enhanced cell apoptosis. Pretreatment of neurons with curcumin reversed the BDNF expression and cell viability in a dose- and time-dependent manner. However, K252a, a Trk receptor inhibitor which is known to inhibit the activity of BDNF, could block the survival-promoting effect of curcumin. In addition, the up-regulation of BDNF levels by curcumin was also suppressed by K252a. Taken together, these results suggest that the neuroprotective effect of curcumin might be mediated via BDNF/TrkB signaling pathway.

Original language	English
Pages (from-to)	84-91
Number of pages	8
Journal	Brain Research
Volume	1210
DOIs	https://doi.org/10.1016/j.brainres.2008.01.104
State	Published - 19 May 2008

Keywords

BDNF
Cerebral cortical neurons
Curcumin
Glutamate excitotoxicity
Neuroprotection
TrkB

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10.1016/j.brainres.2008.01.104

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title = "Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB",

abstract = "Curcumin is a major active component isolated from Curcuma longa. Previously, we have reported its significant antidepressant effect. However, the mechanisms underlying the antidepressant effects are still obscure. In the present study, we explored the effect of curcumin against glutamate excitotoxicity, mainly focusing on the neuroprotective effects of curcumin on the expression of Brain-Derived Neurotrophic Factor (BDNF), which is deeply involved in the etiology and treatment of depression. Exposure of rat cortical neurons to 10 μM glutamate for 24 h caused a significant decrease in BDNF level, accompanied with reduced cell viability and enhanced cell apoptosis. Pretreatment of neurons with curcumin reversed the BDNF expression and cell viability in a dose- and time-dependent manner. However, K252a, a Trk receptor inhibitor which is known to inhibit the activity of BDNF, could block the survival-promoting effect of curcumin. In addition, the up-regulation of BDNF levels by curcumin was also suppressed by K252a. Taken together, these results suggest that the neuroprotective effect of curcumin might be mediated via BDNF/TrkB signaling pathway.",

keywords = "BDNF, Cerebral cortical neurons, Curcumin, Glutamate excitotoxicity, Neuroprotection, TrkB",

author = "Rui Wang and Li, {Ying Bo} and Li, {Yu Hua} and Ying Xu and Wu, {Hong li} and Li, {Xue Jun}",

note = "Funding Information: This work was supported by the National Natural Science Foundation of China (No. 30171090, 30572202, 30270528), 973 Program of the Ministry of Science and Technology in China (No. 2004CB518902), research fund from the Ministry of Education of China No. 20020001082 and 985 and 211 Projects of the Ministry of Education of China.",

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AU - Wang, Rui

AU - Li, Ying Bo

AU - Li, Yu Hua

AU - Xu, Ying

AU - Wu, Hong li

AU - Li, Xue Jun

N1 - Funding Information: This work was supported by the National Natural Science Foundation of China (No. 30171090, 30572202, 30270528), 973 Program of the Ministry of Science and Technology in China (No. 2004CB518902), research fund from the Ministry of Education of China No. 20020001082 and 985 and 211 Projects of the Ministry of Education of China.

PY - 2008/5/19

Y1 - 2008/5/19

N2 - Curcumin is a major active component isolated from Curcuma longa. Previously, we have reported its significant antidepressant effect. However, the mechanisms underlying the antidepressant effects are still obscure. In the present study, we explored the effect of curcumin against glutamate excitotoxicity, mainly focusing on the neuroprotective effects of curcumin on the expression of Brain-Derived Neurotrophic Factor (BDNF), which is deeply involved in the etiology and treatment of depression. Exposure of rat cortical neurons to 10 μM glutamate for 24 h caused a significant decrease in BDNF level, accompanied with reduced cell viability and enhanced cell apoptosis. Pretreatment of neurons with curcumin reversed the BDNF expression and cell viability in a dose- and time-dependent manner. However, K252a, a Trk receptor inhibitor which is known to inhibit the activity of BDNF, could block the survival-promoting effect of curcumin. In addition, the up-regulation of BDNF levels by curcumin was also suppressed by K252a. Taken together, these results suggest that the neuroprotective effect of curcumin might be mediated via BDNF/TrkB signaling pathway.

AB - Curcumin is a major active component isolated from Curcuma longa. Previously, we have reported its significant antidepressant effect. However, the mechanisms underlying the antidepressant effects are still obscure. In the present study, we explored the effect of curcumin against glutamate excitotoxicity, mainly focusing on the neuroprotective effects of curcumin on the expression of Brain-Derived Neurotrophic Factor (BDNF), which is deeply involved in the etiology and treatment of depression. Exposure of rat cortical neurons to 10 μM glutamate for 24 h caused a significant decrease in BDNF level, accompanied with reduced cell viability and enhanced cell apoptosis. Pretreatment of neurons with curcumin reversed the BDNF expression and cell viability in a dose- and time-dependent manner. However, K252a, a Trk receptor inhibitor which is known to inhibit the activity of BDNF, could block the survival-promoting effect of curcumin. In addition, the up-regulation of BDNF levels by curcumin was also suppressed by K252a. Taken together, these results suggest that the neuroprotective effect of curcumin might be mediated via BDNF/TrkB signaling pathway.

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KW - Neuroprotection

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Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB

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