Cross-talk between human neural stem/progenitor cells and peripheral blood mononuclear cells in an allogeneic co-culture model

Hongxia Zhang, Bei Shao, Qichuan Zhuge, Peng Wang, Chengcai Zheng, Weilong Huang, Chenqi Yang, Brian Wang, Dong Ming Su, Kunlin Jin

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Transplantation of human neural stem/progenitor cells (hNSCs) as a regenerative cell replacement therapy holds great promise. However, the underlying mechanisms remain unclear. We, here, focused on the interaction between hNSCs and allogeneic peripheral blood mononuclear cells (PBMCs) in a co-culture model. We found that hNSCs significantly decrease the CD3+ and CD8+ T cells, reduce the gamma delta T cells and increase the regulatory T cells, along with reduced pro-inflammatory cytokines and increased anti-inflammatory cytokines after co-culture. We also found that PBMCs, in turn, significantly promote the proliferation and differentiation of hNSCs. Our data suggest that hNSCs cross-talk with immune cells.

Original languageEnglish
Article numbere0117432
JournalPLoS ONE
Volume10
Issue number2
DOIs
StatePublished - 6 Feb 2015

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