Cross inhibition of drug metabolism by drug metabolites. Increase of zoxazolamine paralysis time by the major metabolite of diphenylhydantoin

W. C. Lubawy; H. B. Kostenbauder; S. A. Stavchansky

Cross inhibition of drug metabolism by drug metabolites. Increase of zoxazolamine paralysis time by the major metabolite of diphenylhydantoin

W. C. Lubawy, H. B. Kostenbauder, S. A. Stavchansky

Pharmaceutical Sciences

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3 Scopus citations

Abstract

The ability of the major metabolite of diphenylhydantoin, 5 (p hydroxyphenyl) 5 phenylhydantoin (HPPH), to affect the duration of action and metabolic rate of type II compounds was examined. Administration of HPPH prolonged the paralysis produced by zoxazolamine in intact rats. Additionally HPPH inhibited the metabolism of zoxazolamine and aniline in rat hepatic 9000 g supernatant. Cross inhibition of drug metabolism by drug metabolites presents a serious potential for drug to drug interactions.

Original language	English
Pages (from-to)	75-82
Number of pages	8
Journal	RES.COMMUN.CHEM.PATH.PHARMACOL.
Volume	8
Issue number	1
State	Published - 1974

Cite this

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title = "Cross inhibition of drug metabolism by drug metabolites. Increase of zoxazolamine paralysis time by the major metabolite of diphenylhydantoin",

abstract = "The ability of the major metabolite of diphenylhydantoin, 5 (p hydroxyphenyl) 5 phenylhydantoin (HPPH), to affect the duration of action and metabolic rate of type II compounds was examined. Administration of HPPH prolonged the paralysis produced by zoxazolamine in intact rats. Additionally HPPH inhibited the metabolism of zoxazolamine and aniline in rat hepatic 9000 g supernatant. Cross inhibition of drug metabolism by drug metabolites presents a serious potential for drug to drug interactions.",

author = "Lubawy, {W. C.} and Kostenbauder, {H. B.} and Stavchansky, {S. A.}",

year = "1974",

language = "English",

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AU - Lubawy, W. C.

AU - Kostenbauder, H. B.

AU - Stavchansky, S. A.

PY - 1974

Y1 - 1974

N2 - The ability of the major metabolite of diphenylhydantoin, 5 (p hydroxyphenyl) 5 phenylhydantoin (HPPH), to affect the duration of action and metabolic rate of type II compounds was examined. Administration of HPPH prolonged the paralysis produced by zoxazolamine in intact rats. Additionally HPPH inhibited the metabolism of zoxazolamine and aniline in rat hepatic 9000 g supernatant. Cross inhibition of drug metabolism by drug metabolites presents a serious potential for drug to drug interactions.

AB - The ability of the major metabolite of diphenylhydantoin, 5 (p hydroxyphenyl) 5 phenylhydantoin (HPPH), to affect the duration of action and metabolic rate of type II compounds was examined. Administration of HPPH prolonged the paralysis produced by zoxazolamine in intact rats. Additionally HPPH inhibited the metabolism of zoxazolamine and aniline in rat hepatic 9000 g supernatant. Cross inhibition of drug metabolism by drug metabolites presents a serious potential for drug to drug interactions.

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M3 - Article

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AN - SCOPUS:0016171599

SN - 0034-5164

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IS - 1

ER -

Cross inhibition of drug metabolism by drug metabolites. Increase of zoxazolamine paralysis time by the major metabolite of diphenylhydantoin

Abstract

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