The ability of the major metabolite of diphenylhydantoin, 5 (p hydroxyphenyl) 5 phenylhydantoin (HPPH), to affect the duration of action and metabolic rate of type II compounds was examined. Administration of HPPH prolonged the paralysis produced by zoxazolamine in intact rats. Additionally HPPH inhibited the metabolism of zoxazolamine and aniline in rat hepatic 9000 g supernatant. Cross inhibition of drug metabolism by drug metabolites presents a serious potential for drug to drug interactions.
|Number of pages||8|
|Publication status||Published - 1 Dec 1974|