CRISPR–Cas9: current and future utilities in ocular diseases

Sam Yacoub, Akash Raola, Gulab Zode

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Genome editing consists of various technologies that involve precise modification of cellular DNA sequences. It utilizes special engineered nucleases that make specific cuts in DNA, which can result in addition, deletion, or replacement of specific nucleotides as well as modification of gene expression or induction epigenetic changes. Genome editing has been extensively used to treat various diseases, including ocular diseases, and also it is currently being utilized to study gene functions. Here, we summarize basic concepts and tools utilized in various genome editing. We further focus on recent applications of CRISPR–Cas9 in various ocular diseases.

Original languageEnglish
Title of host publicationHandbook of Basic and Clinical Ocular Pharmacology and Therapeutics
PublisherElsevier
Pages615-623
Number of pages9
ISBN (Electronic)9780128192917
ISBN (Print)9780128192924
DOIs
StatePublished - 1 Jan 2022

Keywords

  • CRISPR–Cas9
  • DNA
  • enzymes
  • Genome editing

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