Creatine, creatine kinase, and aging

Nathalie Sumien, Ritu A. Shetty, Eric B. Gonzales

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

19 Scopus citations


With an ever aging population, identifying interventions that can alleviate age-related functional declines has become increasingly important. Dietary supplements have taken center stage based on various health claims and have become a multi-million dollar business. One such supplement is creatine, a major contributor to normal cellular physiology. Creatine, an energy source that can be endogenously synthesized or obtained through diet and supplement, is involved primarily in cellular metabolism via ATP replenishment. The goal of this chapter is to summarize how creatine and its associated enzyme, creatine kinase, act under normal physiological conditions, and how altered levels of either may lead to detrimental functional outcomes. Furthermore, we will focus on the effect of aging on the creatine system and how supplementation may affect the aging process and perhaps reverse it.

Original languageEnglish
Title of host publicationSubcellular Biochemistry
PublisherSpringer New York
Number of pages24
StatePublished - 2018

Publication series

NameSubcellular Biochemistry
ISSN (Print)0306-0225


  • Aging
  • Anti-aging intervention
  • Creatine
  • Creatine kinase
  • Motor and cognitive function
  • Muscle function
  • Supplementation


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