TY - JOUR
T1 - COVID-19 in India
T2 - Are biological and environmental factors helping to stem the incidence and severity?
AU - Chakrabarti, Sankha Shubhra
AU - Kaur, Upinder
AU - Banerjee, Anindita
AU - Ganguly, Upasana
AU - Banerjee, Tuhina
AU - Saha, Sarama
AU - Parashar, Gaurav
AU - Prasad, Suvarna
AU - Chakrabarti, Suddhachitta
AU - Mittal, Amit
AU - Agrawal, Bimal Kumar
AU - Rawal, Ravindra Kumar
AU - Zhao, Robert Chunhua
AU - Gambhir, Indrajeet Singh
AU - Khanna, Rahul
AU - Shetty, Ashok K.
AU - Jin, Kunlin
AU - Chakrabarti, Sasanka
N1 - Publisher Copyright:
© 2020 Chakrabarti S et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2020
Y1 - 2020
N2 - The ongoing Corona virus (COVID-19) pandemic has witnessed global political responses of unimaginable proportions. Many nations have implemented lockdowns that involve mandating citizens not to leave their residences for non-essential work. The Indian government has taken appropriate and commendable steps to curtail the community spread of COVID-19. While this may be extremely beneficial, this perspective discusses the other reasons why COVID-19 may have a lesser impact on India. We analyze the current pattern of SARS-CoV-2 transmission, testing, and mortality in India with an emphasis on the importance of mortality as a marker of the clinical relevance of COVID-19 disease. We also analyze the environmental and biological factors which may lessen the impact of COVID-19 in India. The importance of cross-immunity, innate immune responses, ACE polymorphism, and viral genetic mutations are discussed.
AB - The ongoing Corona virus (COVID-19) pandemic has witnessed global political responses of unimaginable proportions. Many nations have implemented lockdowns that involve mandating citizens not to leave their residences for non-essential work. The Indian government has taken appropriate and commendable steps to curtail the community spread of COVID-19. While this may be extremely beneficial, this perspective discusses the other reasons why COVID-19 may have a lesser impact on India. We analyze the current pattern of SARS-CoV-2 transmission, testing, and mortality in India with an emphasis on the importance of mortality as a marker of the clinical relevance of COVID-19 disease. We also analyze the environmental and biological factors which may lessen the impact of COVID-19 in India. The importance of cross-immunity, innate immune responses, ACE polymorphism, and viral genetic mutations are discussed.
KW - ACE2
KW - COVID-19
KW - Cross-immunity
KW - India
KW - Mortality
KW - Transmission
UR - http://www.scopus.com/inward/record.url?scp=85087293175&partnerID=8YFLogxK
U2 - 10.14336/AD.2020.0402
DO - 10.14336/AD.2020.0402
M3 - Review article
AN - SCOPUS:85087293175
SN - 2152-5250
VL - 11
SP - 480
EP - 488
JO - Aging and Disease
JF - Aging and Disease
IS - 3
ER -