Coupling of neurogenesis and angiogenesis after ischemic stroke

Linhui Ruan, Brian Wang, Qichuan Zhuge, Kunlin Jin

Research output: Contribution to journalArticlepeer-review

209 Scopus citations


Stroke is a leading cause of mortality and severe long-term disability worldwide. Development of effective treatment or new therapeutic strategies for ischemic stroke patients is therefore crucial. Ischemic stroke promotes neurogenesis by several growth factors including FGF-2, IGF-1, BDNF, VEGF and chemokines including SDF-1, MCP-1. Stroke-induced angiogenesis is similarly regulated by many factors most notably, eNOS and CSE, VEGF/VEGFR2, and Ang-1/Tie2. Important findings in the last decade have revealed that neurogenesis is not the stand-alone consideration in the fight for full functional recovery from stroke. Angiogenesis has been also shown to be critical in improving post-stroke neurological functional recovery. More than that, recent evidence has shown a highly possible interplay or dependence between stroke-induced neurogenesis and angiogenesis. Moving forward, elucidating the underlying mechanisms of this coupling between stroke-induced neurogenesis and angiogenesis will be of great importance, which will provide the basis for neurorestorative therapy. This article is part of a Special Issue entitled SI: Cell Interactions In Stroke.

Original languageEnglish
Pages (from-to)166-173
Number of pages8
JournalBrain Research
StatePublished - 14 Oct 2015


  • Angiogenesis
  • Cell interaction
  • Ischemia
  • Neurogenesis
  • Stroke


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