Coupling of neurogenesis and angiogenesis after ischemic stroke

Linhui Ruan, Brian Wang, Qichuan Zhuge, Kunlin Jin

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Stroke is a leading cause of mortality and severe long-term disability worldwide. Development of effective treatment or new therapeutic strategies for ischemic stroke patients is therefore crucial. Ischemic stroke promotes neurogenesis by several growth factors including FGF-2, IGF-1, BDNF, VEGF and chemokines including SDF-1, MCP-1. Stroke-induced angiogenesis is similarly regulated by many factors most notably, eNOS and CSE, VEGF/VEGFR2, and Ang-1/Tie2. Important findings in the last decade have revealed that neurogenesis is not the stand-alone consideration in the fight for full functional recovery from stroke. Angiogenesis has been also shown to be critical in improving post-stroke neurological functional recovery. More than that, recent evidence has shown a highly possible interplay or dependence between stroke-induced neurogenesis and angiogenesis. Moving forward, elucidating the underlying mechanisms of this coupling between stroke-induced neurogenesis and angiogenesis will be of great importance, which will provide the basis for neurorestorative therapy. This article is part of a Special Issue entitled SI: Cell Interactions In Stroke.

Original languageEnglish
Pages (from-to)166-173
Number of pages8
JournalBrain Research
Volume1623
DOIs
StatePublished - 14 Oct 2015

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Neurogenesis
Stroke
Vascular Endothelial Growth Factor A
Brain-Derived Neurotrophic Factor
Fibroblast Growth Factor 2
Insulin-Like Growth Factor I
Chemokines
Cell Communication
Intercellular Signaling Peptides and Proteins
Therapeutics
Mortality

Keywords

  • Angiogenesis
  • Cell interaction
  • Ischemia
  • Neurogenesis
  • Stroke

Cite this

Ruan, Linhui ; Wang, Brian ; Zhuge, Qichuan ; Jin, Kunlin. / Coupling of neurogenesis and angiogenesis after ischemic stroke. In: Brain Research. 2015 ; Vol. 1623. pp. 166-173.
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Coupling of neurogenesis and angiogenesis after ischemic stroke. / Ruan, Linhui; Wang, Brian; Zhuge, Qichuan; Jin, Kunlin.

In: Brain Research, Vol. 1623, 14.10.2015, p. 166-173.

Research output: Contribution to journalArticle

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AB - Stroke is a leading cause of mortality and severe long-term disability worldwide. Development of effective treatment or new therapeutic strategies for ischemic stroke patients is therefore crucial. Ischemic stroke promotes neurogenesis by several growth factors including FGF-2, IGF-1, BDNF, VEGF and chemokines including SDF-1, MCP-1. Stroke-induced angiogenesis is similarly regulated by many factors most notably, eNOS and CSE, VEGF/VEGFR2, and Ang-1/Tie2. Important findings in the last decade have revealed that neurogenesis is not the stand-alone consideration in the fight for full functional recovery from stroke. Angiogenesis has been also shown to be critical in improving post-stroke neurological functional recovery. More than that, recent evidence has shown a highly possible interplay or dependence between stroke-induced neurogenesis and angiogenesis. Moving forward, elucidating the underlying mechanisms of this coupling between stroke-induced neurogenesis and angiogenesis will be of great importance, which will provide the basis for neurorestorative therapy. This article is part of a Special Issue entitled SI: Cell Interactions In Stroke.

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