Corticotropin-releasing hormone receptor-1 and 2 activity produces divergent resistance against stress-induced pulmonary Streptococcus pneumoniae infection

Byung Jin Kim, Kay Kayembe, Jerry W. Simecka, Mark Pulse, Harlan P. Jones

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Utilizing a murine model of S. pneumoniae infection and restraint stress, we determined how corticotropin releasing hormone (CRH-R) receptors impacts disease. CRH-R1 (antalarmin) and CRH-R2 (astressin2B) antagonists were administered intraperitoneally prior to restraint stress followed by pulmonary S. pneumoniae infection. CRH-R1 inhibition is not protective against pneumococcal disease induced by stress. Conversely, CRH-R2 inhibition attenuates stress-induced bacterial growth and significantly prevented severe sepsis. Neutrophillic responses were associated with CRH receptor-specific disease outcome providing a potential cellular target for stress-induced susceptibility to the development of severe pneumococcal disease. CRH receptor-mediated effects on immune responses could prove valuable for novel therapeutics.

Original languageEnglish
Pages (from-to)57-65
Number of pages9
JournalJournal of Neuroimmunology
Volume237
Issue number1-2
DOIs
StatePublished - 15 Aug 2011

Keywords

  • Corticotropin releasing hormone
  • Lung
  • Neuroimmune
  • Neutrophils
  • Restraint stress
  • S. pneumoniae
  • Sepsis

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