Correlation of Lipid Profile and Risk of Developing Type 2 Diabetes Mellitus in 10-14 Year Old Children

Research output: Contribution to journalArticle

Abstract

Background/Aims: The role of lipid profile in predicting the risk of Type 2 diabetes mellitus (T2DM) in children is not clearly established. Our aim is to screen non-diabetic children aged 10-14 years for risk of developing T2DM and evaluate the association of abnormal lipids and socioeconomic status (SES). Methods: Data on race/ethnicity, family history, body mass index percentile, blood pressure and presence of neck pigmentation (acanthosis nigricans) were collected from 149 non-diabetic children. Using these factors, children were classified into low risk (<3 risk factors) and high risk (≥3 risk factors) groups. Logistic regression model and chi-square tests were used to evaluate the association of blood lipid profile and demographic variables. Independent t-test was used to compare the ratio of Total Cholesterol (TC) and High Density Lipids (HDL) with T2DM risk. Results: 60% of children were at high risk for developing T2DM. HDL (p<0.001), triglycerides (p=0.02) and TC/HDL ratio (p<.001) were significantly abnormal in high risk group. Low SES showed a marginal association with high risk group. There were no gender or age differences between high and low risk groups. Conclusions: The significant determinants associated with high risk group were modifiable factors providing an opportunity for early intervention and prevention.

Original languageEnglish
Pages (from-to)1695-1704
Number of pages10
JournalCellular Physiology and Biochemistry
Volume39
Issue number5
DOIs
StatePublished - 1 Nov 2016

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Type 2 Diabetes Mellitus
Lipids
Social Class
Logistic Models
Cholesterol
Acanthosis Nigricans
Pigmentation
Chi-Square Distribution
Triglycerides
Body Mass Index
Neck
Demography
Blood Pressure

Keywords

  • Children
  • Lipid profiles
  • Obesity
  • Type 2 diabetes mellitus

Cite this

@article{4868c0e337314e57adfcb23ba09021bb,
title = "Correlation of Lipid Profile and Risk of Developing Type 2 Diabetes Mellitus in 10-14 Year Old Children",
abstract = "Background/Aims: The role of lipid profile in predicting the risk of Type 2 diabetes mellitus (T2DM) in children is not clearly established. Our aim is to screen non-diabetic children aged 10-14 years for risk of developing T2DM and evaluate the association of abnormal lipids and socioeconomic status (SES). Methods: Data on race/ethnicity, family history, body mass index percentile, blood pressure and presence of neck pigmentation (acanthosis nigricans) were collected from 149 non-diabetic children. Using these factors, children were classified into low risk (<3 risk factors) and high risk (≥3 risk factors) groups. Logistic regression model and chi-square tests were used to evaluate the association of blood lipid profile and demographic variables. Independent t-test was used to compare the ratio of Total Cholesterol (TC) and High Density Lipids (HDL) with T2DM risk. Results: 60{\%} of children were at high risk for developing T2DM. HDL (p<0.001), triglycerides (p=0.02) and TC/HDL ratio (p<.001) were significantly abnormal in high risk group. Low SES showed a marginal association with high risk group. There were no gender or age differences between high and low risk groups. Conclusions: The significant determinants associated with high risk group were modifiable factors providing an opportunity for early intervention and prevention.",
keywords = "Children, Lipid profiles, Obesity, Type 2 diabetes mellitus",
author = "Habiba, {Nusrath Mohideen} and Fulda, {Kimberly G.} and Basha, {Riyaz Mahammad} and Deep Shah and Shane Fernando and Bao Nguyen and Yi Xiong and Franks, {Susan Faye} and Sarah Matches and Magie, {Richard D.} and Paul Bowman",
year = "2016",
month = "11",
day = "1",
doi = "10.1159/000447870",
language = "English",
volume = "39",
pages = "1695--1704",
journal = "Cellular Physiology and Biochemistry",
issn = "1015-8987",
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number = "5",

}

TY - JOUR

T1 - Correlation of Lipid Profile and Risk of Developing Type 2 Diabetes Mellitus in 10-14 Year Old Children

AU - Habiba, Nusrath Mohideen

AU - Fulda, Kimberly G.

AU - Basha, Riyaz Mahammad

AU - Shah, Deep

AU - Fernando, Shane

AU - Nguyen, Bao

AU - Xiong, Yi

AU - Franks, Susan Faye

AU - Matches, Sarah

AU - Magie, Richard D.

AU - Bowman, Paul

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Background/Aims: The role of lipid profile in predicting the risk of Type 2 diabetes mellitus (T2DM) in children is not clearly established. Our aim is to screen non-diabetic children aged 10-14 years for risk of developing T2DM and evaluate the association of abnormal lipids and socioeconomic status (SES). Methods: Data on race/ethnicity, family history, body mass index percentile, blood pressure and presence of neck pigmentation (acanthosis nigricans) were collected from 149 non-diabetic children. Using these factors, children were classified into low risk (<3 risk factors) and high risk (≥3 risk factors) groups. Logistic regression model and chi-square tests were used to evaluate the association of blood lipid profile and demographic variables. Independent t-test was used to compare the ratio of Total Cholesterol (TC) and High Density Lipids (HDL) with T2DM risk. Results: 60% of children were at high risk for developing T2DM. HDL (p<0.001), triglycerides (p=0.02) and TC/HDL ratio (p<.001) were significantly abnormal in high risk group. Low SES showed a marginal association with high risk group. There were no gender or age differences between high and low risk groups. Conclusions: The significant determinants associated with high risk group were modifiable factors providing an opportunity for early intervention and prevention.

AB - Background/Aims: The role of lipid profile in predicting the risk of Type 2 diabetes mellitus (T2DM) in children is not clearly established. Our aim is to screen non-diabetic children aged 10-14 years for risk of developing T2DM and evaluate the association of abnormal lipids and socioeconomic status (SES). Methods: Data on race/ethnicity, family history, body mass index percentile, blood pressure and presence of neck pigmentation (acanthosis nigricans) were collected from 149 non-diabetic children. Using these factors, children were classified into low risk (<3 risk factors) and high risk (≥3 risk factors) groups. Logistic regression model and chi-square tests were used to evaluate the association of blood lipid profile and demographic variables. Independent t-test was used to compare the ratio of Total Cholesterol (TC) and High Density Lipids (HDL) with T2DM risk. Results: 60% of children were at high risk for developing T2DM. HDL (p<0.001), triglycerides (p=0.02) and TC/HDL ratio (p<.001) were significantly abnormal in high risk group. Low SES showed a marginal association with high risk group. There were no gender or age differences between high and low risk groups. Conclusions: The significant determinants associated with high risk group were modifiable factors providing an opportunity for early intervention and prevention.

KW - Children

KW - Lipid profiles

KW - Obesity

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