Correlation of heterozygosity and the number of alleles in different frequency classes

Ranajit Chakraborty, R. C. Griffiths

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Analytic expressions for the expectations and variance of the number of alleles with gene frequencies in a specified class are derived in the entire population as well as in a random sample of genes drawn from the population. The correlation of this quantity with heterozygosity at the locus is also obtained. The derivations are given in details for a steady state population of finite size under the infinite allele model of selectively neutral alleles. The results are extended to include weak selection pressures and non-stationarity of the population. The relevance of the correlation of heterozygosity and the number of rare alleles in connection with the neutralist-selectionist controversy is also discussed.

Original languageEnglish
Pages (from-to)205-218
Number of pages14
JournalTheoretical Population Biology
Volume21
Issue number2
DOIs
StatePublished - Apr 1982

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