Abstract
Background and Purpose-Interhemispheric inhibition via the corpus callosum has been proposed as an exacerbating factor in outcome from stroke. Methods-We measured infarct volume and behavioral outcome after middle cerebral artery occlusion in callosotomized rats and acallosal mice. Results-Neither callosotomy in rats nor callosal agenesis in mice improved infarct volume or behavioral outcome after middle cerebral artery occlusion. Conclusions-These findings argue against a role for transcallosal projections in exacerbating focal cerebral ischemia.
| Original language | English |
|---|---|
| Pages (from-to) | 2584-2588 |
| Number of pages | 5 |
| Journal | Stroke |
| Volume | 42 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 2011 |
Keywords
- callosal agenesis
- callosotomy
- corpus callosum
- ischemia
- stroke