Corpus callosum and experimental stroke: Studies in callosotomized rats and acallosal mice

Kunlin Jin, Lin Xie, Fen Sun, Xiaoou Mao, David A. Greenberg

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Background and Purpose-Interhemispheric inhibition via the corpus callosum has been proposed as an exacerbating factor in outcome from stroke. Methods-We measured infarct volume and behavioral outcome after middle cerebral artery occlusion in callosotomized rats and acallosal mice. Results-Neither callosotomy in rats nor callosal agenesis in mice improved infarct volume or behavioral outcome after middle cerebral artery occlusion. Conclusions-These findings argue against a role for transcallosal projections in exacerbating focal cerebral ischemia.

Original languageEnglish
Pages (from-to)2584-2588
Number of pages5
JournalStroke
Volume42
Issue number9
DOIs
StatePublished - Sep 2011

Keywords

  • callosal agenesis
  • callosotomy
  • corpus callosum
  • ischemia
  • stroke

Fingerprint Dive into the research topics of 'Corpus callosum and experimental stroke: Studies in callosotomized rats and acallosal mice'. Together they form a unique fingerprint.

Cite this