Corneal injury: Clinical and molecular aspects

Brayden Barrientez; Sarah E. Nicholas; Amy Whelchel; Rabab Sharif; Jesper Hjortdal; Dimitrios Karamichos

doi:10.1016/j.exer.2019.107709

Corneal injury: Clinical and molecular aspects

Brayden Barrientez, Sarah E. Nicholas, Amy Whelchel, Rabab Sharif, Jesper Hjortdal, Dimitrios Karamichos

Research output: Contribution to journal › Review article › peer-review

38 Scopus citations

Abstract

Currently, over 10 million people worldwide are affected by corneal blindness. Corneal trauma and disease can cause irreversible distortions to the normal structure and physiology of the cornea often leading to corneal transplantation. However, donors are in short supply and risk of rejection is an ever-present concern. Although significant progress has been made in recent years, the wound healing cascade remains complex and not fully understood. Tissue engineering and regenerative medicine are currently at the apex of investigation in the pursuit of novel corneal therapeutics. This review uniquely integrates the clinical and cellular aspects of both corneal trauma and disease and provides a comprehensive view of the most recent findings and potential therapeutics aimed at restoring corneal homeostasis.

Original language	English
Article number	107709
Journal	Experimental eye research
Volume	186
DOIs	https://doi.org/10.1016/j.exer.2019.107709
State	Published - Sep 2019

Keywords

Corneal trauma
Diabetic keratopathy
Fuchs' dystrophy
Keratoconus
Regenerative medicine

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10.1016/j.exer.2019.107709

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title = "Corneal injury: Clinical and molecular aspects",

abstract = "Currently, over 10 million people worldwide are affected by corneal blindness. Corneal trauma and disease can cause irreversible distortions to the normal structure and physiology of the cornea often leading to corneal transplantation. However, donors are in short supply and risk of rejection is an ever-present concern. Although significant progress has been made in recent years, the wound healing cascade remains complex and not fully understood. Tissue engineering and regenerative medicine are currently at the apex of investigation in the pursuit of novel corneal therapeutics. This review uniquely integrates the clinical and cellular aspects of both corneal trauma and disease and provides a comprehensive view of the most recent findings and potential therapeutics aimed at restoring corneal homeostasis.",

keywords = "Corneal trauma, Diabetic keratopathy, Fuchs' dystrophy, Keratoconus, Regenerative medicine",

author = "Brayden Barrientez and Nicholas, {Sarah E.} and Amy Whelchel and Rabab Sharif and Jesper Hjortdal and Dimitrios Karamichos",

note = "Funding Information: This work was supported by the National Institutes of Health [ EY028888 ]. Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

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AU - Whelchel, Amy

AU - Sharif, Rabab

AU - Hjortdal, Jesper

AU - Karamichos, Dimitrios

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AB - Currently, over 10 million people worldwide are affected by corneal blindness. Corneal trauma and disease can cause irreversible distortions to the normal structure and physiology of the cornea often leading to corneal transplantation. However, donors are in short supply and risk of rejection is an ever-present concern. Although significant progress has been made in recent years, the wound healing cascade remains complex and not fully understood. Tissue engineering and regenerative medicine are currently at the apex of investigation in the pursuit of novel corneal therapeutics. This review uniquely integrates the clinical and cellular aspects of both corneal trauma and disease and provides a comprehensive view of the most recent findings and potential therapeutics aimed at restoring corneal homeostasis.

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KW - Diabetic keratopathy

KW - Fuchs' dystrophy

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Corneal injury: Clinical and molecular aspects

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Keywords

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