TY - JOUR
T1 - Convergent carotid sinus nerve and superior laryngeal nerve afferent inputs to neurons in the NTS
AU - Mifflin, Steven W.
PY - 1996/10
Y1 - 1996/10
N2 - A population of 43 neurons in the nucleus of the solitary tract (NTS) was identified in pentobarbital sodium anesthetized, paralyzed, and artificially ventilated cats that received convergent inputs from carotid sinus nerve (CSN) and superior laryngeal nerve (SLN) afferents. In 21 neurons, electrical stimulation of the CSN and SLN each evoked an excitatory postsynaptic potential (EPSP; mean onset latency ± SE of CSN-evoked input = 7.2 ± 0.8 ms, range 2.1-14.1 ms; of SLN-evoked input = 10.3 ± 2.1 ms, range 2.8-46.8 ms). In 22 neurons, electrical stimulation of either the CSN or SLN evoked an EPSP/inhibitory postsynaptic potential (IPSP) sequence (CSN-evoked input - 6.7 ± 0.6 ms, range 2.1-12.2 ms; SLN-evoked input - 8.4 ± 0.8 ms, range 3.0-19.4 ms). Spatial interactions (facilitation, summation, occlusion) and time-dependent inhibitory interactions were observed between the convergent inputs. Natural stimulation of specific receptors indicated that 14 cells received a convergent excitatory input from carotid sinus baroreceptors and laryngeal mechanoreceptors, 10 received a convergent excitatory input from carotid body chemoreceptors and laryngeal mechanoreceptors, and 5 received a convergent excitatory input from baroreceptors, chemoreceptors, and laryngeal mechanoreceptors. The interactions and various patterns of convergence suggest a significant integration of convergent inputs from disparate afferent sources by these neurons.
AB - A population of 43 neurons in the nucleus of the solitary tract (NTS) was identified in pentobarbital sodium anesthetized, paralyzed, and artificially ventilated cats that received convergent inputs from carotid sinus nerve (CSN) and superior laryngeal nerve (SLN) afferents. In 21 neurons, electrical stimulation of the CSN and SLN each evoked an excitatory postsynaptic potential (EPSP; mean onset latency ± SE of CSN-evoked input = 7.2 ± 0.8 ms, range 2.1-14.1 ms; of SLN-evoked input = 10.3 ± 2.1 ms, range 2.8-46.8 ms). In 22 neurons, electrical stimulation of either the CSN or SLN evoked an EPSP/inhibitory postsynaptic potential (IPSP) sequence (CSN-evoked input - 6.7 ± 0.6 ms, range 2.1-12.2 ms; SLN-evoked input - 8.4 ± 0.8 ms, range 3.0-19.4 ms). Spatial interactions (facilitation, summation, occlusion) and time-dependent inhibitory interactions were observed between the convergent inputs. Natural stimulation of specific receptors indicated that 14 cells received a convergent excitatory input from carotid sinus baroreceptors and laryngeal mechanoreceptors, 10 received a convergent excitatory input from carotid body chemoreceptors and laryngeal mechanoreceptors, and 5 received a convergent excitatory input from baroreceptors, chemoreceptors, and laryngeal mechanoreceptors. The interactions and various patterns of convergence suggest a significant integration of convergent inputs from disparate afferent sources by these neurons.
KW - baroreceptor
KW - chemoreceptor
KW - laryngeal mechanoreceptors
KW - larynx
KW - neural control of circulation
KW - neural control of respiration
UR - http://www.scopus.com/inward/record.url?scp=0029858938&partnerID=8YFLogxK
U2 - 10.1152/ajpregu.1996.271.4.r870
DO - 10.1152/ajpregu.1996.271.4.r870
M3 - Article
C2 - 8897976
AN - SCOPUS:0029858938
SN - 0363-6119
VL - 271
SP - R870-R880
JO - American Journal of Physiology - Regulatory Integrative and Comparative Physiology
JF - American Journal of Physiology - Regulatory Integrative and Comparative Physiology
IS - 4 40-4
ER -