Contribution of CD8+ T cells to gamma interferon production in human tuberculosis

H. Shams, B. Wizel, S. E. Weis, B. Samten, P. F. Barnes

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

The proportions of peripheral blood mononuclear cells (PBMC), CD4+ T cells, and CD8+ T cells that produce gamma interferon (IFN-γ) in response to Mycobacterium tuberculosis were markedly reduced in tuberculosis patients, particularly in those with severe disease. Depletion of CD4+ but not CD8+ cells prior to stimulation of PBMC with M. tuberculosis abolished IFN-γ production. These results show that (i) IFN-γ production by CD8+ and CD4+ cells correlates with the clinical manifestations of M. tuberculosis infection and (ii) IFN-γ production by CD8+ cells depends on CD4+ cells.

Original languageEnglish
Pages (from-to)3497-3501
Number of pages5
JournalInfection and Immunity
Volume69
Issue number5
DOIs
StatePublished - 2001

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