Contribution of Adipose-Derived Cells to Skin Wound Healing

Barbara Gawronska-Kozak, Joanna Bukowska, Xiying Wu, Amy Lin Strong, Trivia Frazier, Bruce A. Bunnell, Jeffrey M. Gimble

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


While the use of adipose tissue transplantation in wound healing dates back over a century in the surgical literature, it is only within the past two decades that scientists and physicians have begun to more fully appreciate the cellular and molecular basis for the regenerative effects of this organ. Adipose tissue is a dynamic organ participating in biomechanical, endocrine, immunologic, metabolic, regenerative, and reproductive physiology. The tissue contains a heterogeneous cell population that includes, in addition to mature adipocytes, endothelial, fibroblast, lymphoid, myeloid, pericyte, preadipocyte, smooth muscle, and stromal/stem cells. These cell populations can be isolated by enzymatic digestion or mechanical disruption of the adipose tissue and are identified as "stromal vascular fraction" (SVF) cells as an uncultured isolate or as "adipose-derived stromal/stem cells" (ASC) after plastic adhesion and culture expansion. In vitro and in vivo studies in preclinical studies have demonstrated the feasibility and potential utility of administering ASC and SVF cells to accelerate and enhance wound healing in skin defect models, including full thickness excisional injuries and pressure ulcers. These findings are being extended to FDA approved clinical trials. This application of ASC within regenerative medicine will require further development at the preclinical level as well as the performance of randomized controlled clinical trials to document the superiority of adipose-derived cell therapy over current therapeutic modalities.

Original languageEnglish
Title of host publicationWound Healing
Subtitle of host publicationStem Cells Repair and Restorations, Basic and Clinical Aspects
Number of pages13
ISBN (Electronic)9781119282518
ISBN (Print)9781119282488
StatePublished - 23 Jan 2018


  • Adipose stromal/stem cells
  • Animal models
  • Clinical outcomes
  • Skin wound healing


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