Contra-directional expression of serum homocysteine and uric acid as important biomarkers of multiple system atrophy severity: A cross-sectional study

Dan Chen, Xiaobo Wei, Jing Zou, Rui Wang, Xu Liu, Xiaofeng Xu, Jianjun Lu, Zhanhang Wang, Beisha Tang, Brian Wang, Kunlin Jin, Qing Wang

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Aim: There is evidence suggesting that inflammatory responses play a critical role in the pathogenesis of multiple system atrophy (MSA). Whether inflammatory mediators can be used as reliable biomarkers to detect the severity and progression of MSA remains largely unknown. Methods: We performed a cross-sectional study that included 47 patients with MSA and 50 healthy age-matched controls. Serum levels of homocysteine (Hcy), uric acid (UA), and C-reactive protein (CRP) were measured. These levels positively correlated with the severity of MSA, based on both motor and non-motor symptoms. Several scales were used to rate the severity of MSA, including the Unified multiple system atrophy rating scale, Parkinson’s disease sleep scale, Non-motor Symptoms Scale, the Schwab & England activities of daily living scale, Webster Scale, modified Hoehn and Yahr staging scale, and the Mini-Mental State Examination. Receiver operating characteristic (ROC) curves was applied to map the diagnostic accuracy of MSA against healthy subjects.  Results: Compared with healthy subjects, we found that serum Hcy was higher, UA was lower, and CRP levels were unchanged in MSA patients. These findings were especially prominent in male patients. No significant differences of serum Hcy and UA were observed between patients of MSA and PD. Interestingly, there was a significant correlation between Hcy levels and MSA severity such as movement dysfunction, declined cognition, and cardiovascular symptoms. Additionally, the ROCcurveforthe combination of Hcy and UA (AUC 0.736) showed potential diagnostic value in discriminating MSA from healthy subjects. Conclusion: Our findings suggest that the inflammatory mediators Hcy and UA may play important roles in the pathogenesis of MSA. The measurement of serum Hcy and UA levels could then be a useful tool to accurately distinguish MSA from healthy subjects.

Original languageEnglish
Article number247
JournalFrontiers in Cellular Neuroscience
Volume9
Issue numberJULY
DOIs
StatePublished - 6 Jul 2015

Fingerprint

Multiple System Atrophy
Homocysteine
Uric Acid
Cross-Sectional Studies
Biomarkers
Serum
Healthy Volunteers
C-Reactive Protein
Activities of Daily Living
ROC Curve
England
Cognition
Area Under Curve
Parkinson Disease

Keywords

  • Cognition
  • Homocysteine
  • Inflammation
  • Multiple system atrophy
  • Uric acid

Cite this

Chen, Dan ; Wei, Xiaobo ; Zou, Jing ; Wang, Rui ; Liu, Xu ; Xu, Xiaofeng ; Lu, Jianjun ; Wang, Zhanhang ; Tang, Beisha ; Wang, Brian ; Jin, Kunlin ; Wang, Qing. / Contra-directional expression of serum homocysteine and uric acid as important biomarkers of multiple system atrophy severity : A cross-sectional study. In: Frontiers in Cellular Neuroscience. 2015 ; Vol. 9, No. JULY.
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abstract = "Aim: There is evidence suggesting that inflammatory responses play a critical role in the pathogenesis of multiple system atrophy (MSA). Whether inflammatory mediators can be used as reliable biomarkers to detect the severity and progression of MSA remains largely unknown. Methods: We performed a cross-sectional study that included 47 patients with MSA and 50 healthy age-matched controls. Serum levels of homocysteine (Hcy), uric acid (UA), and C-reactive protein (CRP) were measured. These levels positively correlated with the severity of MSA, based on both motor and non-motor symptoms. Several scales were used to rate the severity of MSA, including the Unified multiple system atrophy rating scale, Parkinson’s disease sleep scale, Non-motor Symptoms Scale, the Schwab & England activities of daily living scale, Webster Scale, modified Hoehn and Yahr staging scale, and the Mini-Mental State Examination. Receiver operating characteristic (ROC) curves was applied to map the diagnostic accuracy of MSA against healthy subjects.  Results: Compared with healthy subjects, we found that serum Hcy was higher, UA was lower, and CRP levels were unchanged in MSA patients. These findings were especially prominent in male patients. No significant differences of serum Hcy and UA were observed between patients of MSA and PD. Interestingly, there was a significant correlation between Hcy levels and MSA severity such as movement dysfunction, declined cognition, and cardiovascular symptoms. Additionally, the ROCcurveforthe combination of Hcy and UA (AUC 0.736) showed potential diagnostic value in discriminating MSA from healthy subjects. Conclusion: Our findings suggest that the inflammatory mediators Hcy and UA may play important roles in the pathogenesis of MSA. The measurement of serum Hcy and UA levels could then be a useful tool to accurately distinguish MSA from healthy subjects.",
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Contra-directional expression of serum homocysteine and uric acid as important biomarkers of multiple system atrophy severity : A cross-sectional study. / Chen, Dan; Wei, Xiaobo; Zou, Jing; Wang, Rui; Liu, Xu; Xu, Xiaofeng; Lu, Jianjun; Wang, Zhanhang; Tang, Beisha; Wang, Brian; Jin, Kunlin; Wang, Qing.

In: Frontiers in Cellular Neuroscience, Vol. 9, No. JULY, 247, 06.07.2015.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Contra-directional expression of serum homocysteine and uric acid as important biomarkers of multiple system atrophy severity

T2 - A cross-sectional study

AU - Chen, Dan

AU - Wei, Xiaobo

AU - Zou, Jing

AU - Wang, Rui

AU - Liu, Xu

AU - Xu, Xiaofeng

AU - Lu, Jianjun

AU - Wang, Zhanhang

AU - Tang, Beisha

AU - Wang, Brian

AU - Jin, Kunlin

AU - Wang, Qing

PY - 2015/7/6

Y1 - 2015/7/6

N2 - Aim: There is evidence suggesting that inflammatory responses play a critical role in the pathogenesis of multiple system atrophy (MSA). Whether inflammatory mediators can be used as reliable biomarkers to detect the severity and progression of MSA remains largely unknown. Methods: We performed a cross-sectional study that included 47 patients with MSA and 50 healthy age-matched controls. Serum levels of homocysteine (Hcy), uric acid (UA), and C-reactive protein (CRP) were measured. These levels positively correlated with the severity of MSA, based on both motor and non-motor symptoms. Several scales were used to rate the severity of MSA, including the Unified multiple system atrophy rating scale, Parkinson’s disease sleep scale, Non-motor Symptoms Scale, the Schwab & England activities of daily living scale, Webster Scale, modified Hoehn and Yahr staging scale, and the Mini-Mental State Examination. Receiver operating characteristic (ROC) curves was applied to map the diagnostic accuracy of MSA against healthy subjects.  Results: Compared with healthy subjects, we found that serum Hcy was higher, UA was lower, and CRP levels were unchanged in MSA patients. These findings were especially prominent in male patients. No significant differences of serum Hcy and UA were observed between patients of MSA and PD. Interestingly, there was a significant correlation between Hcy levels and MSA severity such as movement dysfunction, declined cognition, and cardiovascular symptoms. Additionally, the ROCcurveforthe combination of Hcy and UA (AUC 0.736) showed potential diagnostic value in discriminating MSA from healthy subjects. Conclusion: Our findings suggest that the inflammatory mediators Hcy and UA may play important roles in the pathogenesis of MSA. The measurement of serum Hcy and UA levels could then be a useful tool to accurately distinguish MSA from healthy subjects.

AB - Aim: There is evidence suggesting that inflammatory responses play a critical role in the pathogenesis of multiple system atrophy (MSA). Whether inflammatory mediators can be used as reliable biomarkers to detect the severity and progression of MSA remains largely unknown. Methods: We performed a cross-sectional study that included 47 patients with MSA and 50 healthy age-matched controls. Serum levels of homocysteine (Hcy), uric acid (UA), and C-reactive protein (CRP) were measured. These levels positively correlated with the severity of MSA, based on both motor and non-motor symptoms. Several scales were used to rate the severity of MSA, including the Unified multiple system atrophy rating scale, Parkinson’s disease sleep scale, Non-motor Symptoms Scale, the Schwab & England activities of daily living scale, Webster Scale, modified Hoehn and Yahr staging scale, and the Mini-Mental State Examination. Receiver operating characteristic (ROC) curves was applied to map the diagnostic accuracy of MSA against healthy subjects.  Results: Compared with healthy subjects, we found that serum Hcy was higher, UA was lower, and CRP levels were unchanged in MSA patients. These findings were especially prominent in male patients. No significant differences of serum Hcy and UA were observed between patients of MSA and PD. Interestingly, there was a significant correlation between Hcy levels and MSA severity such as movement dysfunction, declined cognition, and cardiovascular symptoms. Additionally, the ROCcurveforthe combination of Hcy and UA (AUC 0.736) showed potential diagnostic value in discriminating MSA from healthy subjects. Conclusion: Our findings suggest that the inflammatory mediators Hcy and UA may play important roles in the pathogenesis of MSA. The measurement of serum Hcy and UA levels could then be a useful tool to accurately distinguish MSA from healthy subjects.

KW - Cognition

KW - Homocysteine

KW - Inflammation

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KW - Uric acid

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