Concise review: Adipose-derived stromal vascular fraction cells and stem cells: Let's not get lost in translation

Jeffrey M. Gimble, Bruce A. Bunnell, Ernest S. Chiu, Farshid Guilak

Research output: Contribution to journalArticlepeer-review

167 Scopus citations

Abstract

Subcutaneous fat has emerged as an alternative tissue source for stromal/stem cells in regenerative medicine. Over the past decade, international research efforts have established a wealth of basic science and preclinical evidence regarding the differentiation potential and regenerative properties of both freshly processed, heterogeneous stromal vascular fraction cells and culture expanded, relatively homogeneous adipose-derived stromal/stem cells. the stage has been set for clinicians to translate adipose-derived cells from the bench to the bedside; however, this process will involve "development" steps that fall outside of traditional "hypothesis-driven, mechanism-based'' paradigm. This concise review examines the next stages of the development process for therapeutic applications of adipose-derived cells and highlights the current state of the art regarding clinical trials. It is recommended that the experiments addressing these issues be reported comprehensively in the peer-review literature. This transparency will accelerate the standardization and reproducibility of adipose-derived cell therapies with respect to their efficacy and safety.

Original languageEnglish
Pages (from-to)749-754
Number of pages6
JournalStem Cells
Volume29
Issue number5
DOIs
StatePublished - May 2011

Keywords

  • Adipogenesis
  • Adipose
  • Adult stem cells
  • Cellular therapy
  • Clinical translation
  • Current Good Manufacturing Practices
  • Stem cell transplantation
  • Stromal cells

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