Complexity of force output during static exercise in individuals with Down syndrome

Kevin S. Heffernan, Jacob J. Sosnoff, Edward Ofori, Sae Young Jae, Tracy Baynard, Scott R. Collier, Styliani Goulopoulou, Arturo Figueroa, Jeffrey A. Woods, Kenneth H. Pitetti, Bo Fernhall

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Abstract

Force variability is greater in individuals with Down syndrome (DS) compared with persons without DS and is similar to that seen with normal aging. The purpose of this study was to examine the structure (in both time and frequency domains) of force output variability in persons with DS to determine whether deficits in force control are similar between individuals with DS and older adults. An isometric handgrip task at a constant force (30% of maximal voluntary contraction) was completed by individuals with DS (n = 29, age 26 yr), and healthy young (n = 26, age 27 yr) and older (n = 33, age 70 yr) individuals. Mean, standard deviation (SD), and coefficient of variation (CV) were used to analyze the magnitude of force output variability. Spectral analysis and approximate entropy (ApEn) were used to analyze the structure of force output variability. Mean force output for DS was lower than in young controls (P < 0.05) but no different from old controls. Individuals with DS had greater SD and CV than young and old controls (P < 0.05). The DS group had a significantly greater proportion of spectral power within the 0-to 4-Hz bandwidth than the young and older controls (P < 0.05). The DS group had significantly lower ApEn values than the young controls (P < 0.05), but there were no differences in ApEn between the DS group and the old controls (P > 0.05). In conclusion, young persons with DS demonstrate enhanced temporal structure and greater amplitude of low-frequency oscillations in the force output signal than age-matched non-DS peers. Interestingly, young persons with DS and older persons without DS have similar time-dependent structure of force output variability. This would suggest a possible link between premature aging and less complex force output in persons with DS.

Original languageEnglish
Pages (from-to)1227-1233
Number of pages7
JournalJournal of Applied Physiology
Volume106
Issue number4
DOIs
StatePublished - 1 Apr 2009

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Down Syndrome
Premature Aging
Entropy

Keywords

  • Approximate entropy
  • Motor control

Cite this

Heffernan, K. S., Sosnoff, J. J., Ofori, E., Jae, S. Y., Baynard, T., Collier, S. R., ... Fernhall, B. (2009). Complexity of force output during static exercise in individuals with Down syndrome. Journal of Applied Physiology, 106(4), 1227-1233. https://doi.org/10.1152/japplphysiol.90555.2008
Heffernan, Kevin S. ; Sosnoff, Jacob J. ; Ofori, Edward ; Jae, Sae Young ; Baynard, Tracy ; Collier, Scott R. ; Goulopoulou, Styliani ; Figueroa, Arturo ; Woods, Jeffrey A. ; Pitetti, Kenneth H. ; Fernhall, Bo. / Complexity of force output during static exercise in individuals with Down syndrome. In: Journal of Applied Physiology. 2009 ; Vol. 106, No. 4. pp. 1227-1233.
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abstract = "Force variability is greater in individuals with Down syndrome (DS) compared with persons without DS and is similar to that seen with normal aging. The purpose of this study was to examine the structure (in both time and frequency domains) of force output variability in persons with DS to determine whether deficits in force control are similar between individuals with DS and older adults. An isometric handgrip task at a constant force (30{\%} of maximal voluntary contraction) was completed by individuals with DS (n = 29, age 26 yr), and healthy young (n = 26, age 27 yr) and older (n = 33, age 70 yr) individuals. Mean, standard deviation (SD), and coefficient of variation (CV) were used to analyze the magnitude of force output variability. Spectral analysis and approximate entropy (ApEn) were used to analyze the structure of force output variability. Mean force output for DS was lower than in young controls (P < 0.05) but no different from old controls. Individuals with DS had greater SD and CV than young and old controls (P < 0.05). The DS group had a significantly greater proportion of spectral power within the 0-to 4-Hz bandwidth than the young and older controls (P < 0.05). The DS group had significantly lower ApEn values than the young controls (P < 0.05), but there were no differences in ApEn between the DS group and the old controls (P > 0.05). In conclusion, young persons with DS demonstrate enhanced temporal structure and greater amplitude of low-frequency oscillations in the force output signal than age-matched non-DS peers. Interestingly, young persons with DS and older persons without DS have similar time-dependent structure of force output variability. This would suggest a possible link between premature aging and less complex force output in persons with DS.",
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Heffernan, KS, Sosnoff, JJ, Ofori, E, Jae, SY, Baynard, T, Collier, SR, Goulopoulou, S, Figueroa, A, Woods, JA, Pitetti, KH & Fernhall, B 2009, 'Complexity of force output during static exercise in individuals with Down syndrome', Journal of Applied Physiology, vol. 106, no. 4, pp. 1227-1233. https://doi.org/10.1152/japplphysiol.90555.2008

Complexity of force output during static exercise in individuals with Down syndrome. / Heffernan, Kevin S.; Sosnoff, Jacob J.; Ofori, Edward; Jae, Sae Young; Baynard, Tracy; Collier, Scott R.; Goulopoulou, Styliani; Figueroa, Arturo; Woods, Jeffrey A.; Pitetti, Kenneth H.; Fernhall, Bo.

In: Journal of Applied Physiology, Vol. 106, No. 4, 01.04.2009, p. 1227-1233.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Complexity of force output during static exercise in individuals with Down syndrome

AU - Heffernan, Kevin S.

AU - Sosnoff, Jacob J.

AU - Ofori, Edward

AU - Jae, Sae Young

AU - Baynard, Tracy

AU - Collier, Scott R.

AU - Goulopoulou, Styliani

AU - Figueroa, Arturo

AU - Woods, Jeffrey A.

AU - Pitetti, Kenneth H.

AU - Fernhall, Bo

PY - 2009/4/1

Y1 - 2009/4/1

N2 - Force variability is greater in individuals with Down syndrome (DS) compared with persons without DS and is similar to that seen with normal aging. The purpose of this study was to examine the structure (in both time and frequency domains) of force output variability in persons with DS to determine whether deficits in force control are similar between individuals with DS and older adults. An isometric handgrip task at a constant force (30% of maximal voluntary contraction) was completed by individuals with DS (n = 29, age 26 yr), and healthy young (n = 26, age 27 yr) and older (n = 33, age 70 yr) individuals. Mean, standard deviation (SD), and coefficient of variation (CV) were used to analyze the magnitude of force output variability. Spectral analysis and approximate entropy (ApEn) were used to analyze the structure of force output variability. Mean force output for DS was lower than in young controls (P < 0.05) but no different from old controls. Individuals with DS had greater SD and CV than young and old controls (P < 0.05). The DS group had a significantly greater proportion of spectral power within the 0-to 4-Hz bandwidth than the young and older controls (P < 0.05). The DS group had significantly lower ApEn values than the young controls (P < 0.05), but there were no differences in ApEn between the DS group and the old controls (P > 0.05). In conclusion, young persons with DS demonstrate enhanced temporal structure and greater amplitude of low-frequency oscillations in the force output signal than age-matched non-DS peers. Interestingly, young persons with DS and older persons without DS have similar time-dependent structure of force output variability. This would suggest a possible link between premature aging and less complex force output in persons with DS.

AB - Force variability is greater in individuals with Down syndrome (DS) compared with persons without DS and is similar to that seen with normal aging. The purpose of this study was to examine the structure (in both time and frequency domains) of force output variability in persons with DS to determine whether deficits in force control are similar between individuals with DS and older adults. An isometric handgrip task at a constant force (30% of maximal voluntary contraction) was completed by individuals with DS (n = 29, age 26 yr), and healthy young (n = 26, age 27 yr) and older (n = 33, age 70 yr) individuals. Mean, standard deviation (SD), and coefficient of variation (CV) were used to analyze the magnitude of force output variability. Spectral analysis and approximate entropy (ApEn) were used to analyze the structure of force output variability. Mean force output for DS was lower than in young controls (P < 0.05) but no different from old controls. Individuals with DS had greater SD and CV than young and old controls (P < 0.05). The DS group had a significantly greater proportion of spectral power within the 0-to 4-Hz bandwidth than the young and older controls (P < 0.05). The DS group had significantly lower ApEn values than the young controls (P < 0.05), but there were no differences in ApEn between the DS group and the old controls (P > 0.05). In conclusion, young persons with DS demonstrate enhanced temporal structure and greater amplitude of low-frequency oscillations in the force output signal than age-matched non-DS peers. Interestingly, young persons with DS and older persons without DS have similar time-dependent structure of force output variability. This would suggest a possible link between premature aging and less complex force output in persons with DS.

KW - Approximate entropy

KW - Motor control

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