Comparisons of familial DNA Database searching strategies

Jianye Ge, Ranajit Chakraborty, Arthur Eisenberg, Bruce Budowle

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

The current familial searching strategies are generally based on either Identity-By-State (IBS) (i.e., number of shared alleles) or likelihood ratio (i.e., kinship index [KI]) assessments. In this study, the expected IBS match probabilities given relationships and the logic of the likelihood ratio method were addressed. Further, the false-positive and false-negative rates of the strategies were compared analytically or by simulations using Caucasian population data of the 13 CODIS Short Tandem Repeat (STR). IBS≥15, IBS≥16, KI≥1000, or KI≥10,000 were found to be good thresholds for balancing false-positive and false-negative rates. IBS≥17 and/or KI≥1,000,000 can exclude the majority of candidate profiles in the database, either related or not, and may be an initial screening option if a small candidate list is desired. Polices combining both IBS and KI can provide higher accuracy. Typing additional STRs can provide better searching performance, and lineage markers can be extremely useful for reducing false rates.

Original languageEnglish
Pages (from-to)1448-1456
Number of pages9
JournalJournal of Forensic Sciences
Volume56
Issue number6
DOIs
StatePublished - 1 Nov 2011

Keywords

  • DNA database
  • Familial searching
  • Forensic science
  • Identity-By-State
  • Kinship analysis
  • Likelihood ratio
  • Moderate stringency match

Fingerprint Dive into the research topics of 'Comparisons of familial DNA Database searching strategies'. Together they form a unique fingerprint.

  • Cite this