Comparison of the binding and functional properties of two structurally different D2 dopamine receptor subtype selective compounds

Medicine & Life Sciences

• 1-((5-methoxy-1H-indol-3-yl)methyl)-4-(4-(methylthio)phenyl)piperidin-4-ol 100%
• Dopamine D3 Receptors 58%
• Dopamine D2 Receptors 48%
• 7-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butoxy)-3,4-dihydroquinolin-2(1H)-one 35%
• Adenylyl Cyclases 27%
• human DRD2 protein 24%
• G Protein-Coupled Inwardly-Rectifying Potassium Channels 23%
• Dopamine D2 Receptor Antagonists 19%
• Ligands 19%
• Aripiprazole 18%
• indole 17%
• GTP-Binding Proteins 13%
• In Vitro Techniques 5%

Chemical Compounds

• Dopamine 38%
• Antagonist 12%
• Aripiprazole 11%
• Partial Agonist 8%
• Indole 6%
• Ligand 5%