TY - JOUR
T1 - Comparison of the actions of γ-butyrolactone and 1,4-butanediol in Swiss-Webster mice
AU - De Fiebre, Christopher M.
AU - De Fiebre, Nancy Ellen C.
AU - Coleman, Scott L.
AU - Forster, Michael J.
N1 - Funding Information:
This work was supported in part by AA-11597 and from support provided by the University of North Texas Health Science Center at Fort Worth Intramural Research Program.
PY - 2004/4
Y1 - 2004/4
N2 - The abuse of γ-hydroxybutyrate (GHB) and two of its precursors, γ-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) are recognized as a public health concern. Here, we report dose-response and time-course analyses for effects of GBL and 1,4-BD on locomotor activity and body temperature in Swiss-Webster mice. Locomotor activity was measured for 2 h following a single injection of one of four doses of each agent plus a saline vehicle control. At 50 mg/kg, GBL produced an initial depression of locomotor activity which was followed by stimulation of locomotor activity. In contrast, 1,4-BD at 50 mg/kg stimulated locomotor activity without producing any depression of activity. At higher doses, GBL produced primarily a dose-dependent decrease in locomotor activity that returned to baseline within 50 min. In contrast, 1,4-BD produced an initial depression which was followed by stimulation of activity. Body temperature was measured rectally across a 2.5-h time course following injection with either agent. Both drugs produced hypothermia with peak effects occurring at 20 and 30 min for both drugs for the lower and higher dose, respectively. At 150 mg/kg, GBL produced a greater hypothermic response; however, no differences in hypothermic response were observed at 100 mg/kg. These studies demonstrate that the precursor drugs to GHB have some differential actions from each other.
AB - The abuse of γ-hydroxybutyrate (GHB) and two of its precursors, γ-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) are recognized as a public health concern. Here, we report dose-response and time-course analyses for effects of GBL and 1,4-BD on locomotor activity and body temperature in Swiss-Webster mice. Locomotor activity was measured for 2 h following a single injection of one of four doses of each agent plus a saline vehicle control. At 50 mg/kg, GBL produced an initial depression of locomotor activity which was followed by stimulation of locomotor activity. In contrast, 1,4-BD at 50 mg/kg stimulated locomotor activity without producing any depression of activity. At higher doses, GBL produced primarily a dose-dependent decrease in locomotor activity that returned to baseline within 50 min. In contrast, 1,4-BD produced an initial depression which was followed by stimulation of activity. Body temperature was measured rectally across a 2.5-h time course following injection with either agent. Both drugs produced hypothermia with peak effects occurring at 20 and 30 min for both drugs for the lower and higher dose, respectively. At 150 mg/kg, GBL produced a greater hypothermic response; however, no differences in hypothermic response were observed at 100 mg/kg. These studies demonstrate that the precursor drugs to GHB have some differential actions from each other.
KW - 1,4-Butanediol
KW - Club drugs
KW - Hypothermia
KW - Locomotor activity
KW - γ-Butyrolactone
KW - γ-Hydroxybutyrate
UR - http://www.scopus.com/inward/record.url?scp=1942455422&partnerID=8YFLogxK
U2 - 10.1016/j.pbb.2004.01.009
DO - 10.1016/j.pbb.2004.01.009
M3 - Article
C2 - 15099915
AN - SCOPUS:1942455422
SN - 0091-3057
VL - 77
SP - 705
EP - 710
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
IS - 4
ER -