TY - JOUR
T1 - Comparison of orientation and rotational motion of skeletal muscle cross-bridges containing phosphorylated and dephosphorylated myosin regulatory light chain
AU - Midde, Krishna
AU - Ryan Rich, Rich
AU - Peter Marandos, Marandos
AU - Rafal Fudala, Fudala
AU - Amy Li, Li
AU - Ignacy Gryczynski, Gryczynski
AU - Borejdo, Julian
PY - 2013/3/8
Y1 - 2013/3/8
N2 - Background: Myosin cross-bridges containing phosphorylated and dephosphorylated regulatory light chain may be different. Results: Relaxed cross-bridges, but not active ones, are better ordered in muscle containing dephosphorylated RLC than phosphorylated RLC; they both rotate equally slowly. During contraction phosphorylated cross-bridges rotate faster. Conclusion: Both types of cross-bridges are functionally different. Significance: Phosphorylation of skeletal myosin RLC plays a role in regulation of skeletal muscle contraction.
AB - Background: Myosin cross-bridges containing phosphorylated and dephosphorylated regulatory light chain may be different. Results: Relaxed cross-bridges, but not active ones, are better ordered in muscle containing dephosphorylated RLC than phosphorylated RLC; they both rotate equally slowly. During contraction phosphorylated cross-bridges rotate faster. Conclusion: Both types of cross-bridges are functionally different. Significance: Phosphorylation of skeletal myosin RLC plays a role in regulation of skeletal muscle contraction.
UR - http://www.scopus.com/inward/record.url?scp=84874868937&partnerID=8YFLogxK
U2 - 10.1074/jbc.M112.434209
DO - 10.1074/jbc.M112.434209
M3 - Article
C2 - 23319584
AN - SCOPUS:84874868937
VL - 288
SP - 7012
EP - 7023
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 10
ER -