Abstract
Background: Myosin cross-bridges containing phosphorylated and dephosphorylated regulatory light chain may be different. Results: Relaxed cross-bridges, but not active ones, are better ordered in muscle containing dephosphorylated RLC than phosphorylated RLC; they both rotate equally slowly. During contraction phosphorylated cross-bridges rotate faster. Conclusion: Both types of cross-bridges are functionally different. Significance: Phosphorylation of skeletal myosin RLC plays a role in regulation of skeletal muscle contraction.
| Original language | English |
|---|---|
| Pages (from-to) | 7012-7023 |
| Number of pages | 12 |
| Journal | Journal of Biological Chemistry |
| Volume | 288 |
| Issue number | 10 |
| DOIs | |
| State | Published - 8 Mar 2013 |
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Midde, K., Ryan Rich, R., Peter Marandos, M., Rafal Fudala, F., Amy Li, L., Ignacy Gryczynski, G., & Borejdo, J. (2013). Comparison of orientation and rotational motion of skeletal muscle cross-bridges containing phosphorylated and dephosphorylated myosin regulatory light chain. Journal of Biological Chemistry, 288(10), 7012-7023. https://doi.org/10.1074/jbc.M112.434209