Comparison of haloperidol and reduced haloperidol plasma levels in four different ethnic populations

Michael W. Jann; Chang Wen-Ho; Y. W.Francis Lam; Hai G. Hwu; Lin Hsin-Nan; Chen Horng; Teng Y. Chen; Lin Shih-Ku; Chien Ching-Piao; Chester M. Davis; Larry Ereshefsky; Stephen R. Saklad; Ann L. Richards; William M. Scholteis

doi:10.1016/0278-5846(92)90070-U

Comparison of haloperidol and reduced haloperidol plasma levels in four different ethnic populations

Michael W. Jann, Chang Wen-Ho, Y. W.Francis Lam, Hai G. Hwu, Lin Hsin-Nan, Chen Horng, Teng Y. Chen, Lin Shih-Ku, Chien Ching-Piao, Chester M. Davis, Larry Ereshefsky, Stephen R. Saklad, Ann L. Richards, William M. Scholteis

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Abstract

1. 1. Plasma haloperidol and reduced haloperidol concentration were measured in four ethnic populations. 2. 2. Plasma samples were obtained under steady-state conditions and obtained 10-12 hours post bedtime dose and prior to the morning dose. 3. 3. Haloperidol and reduced haloperidol plasma levels were assayed by radioimmunoassay and liquid chromatography. 4. 4. A wide interpatient variability between haloperidol dose and plasma concentration was observed for each ethnic group. 5. 5. The Chinese group differed from the other ethnic populations. 6. 6. A nonlinear relationship was observed between haloperidol and reduced haloperidol plasma levels in each ethnic group. Further, the relationship of haloperidol to reduced haloperidol plasma levels differed for each ethnic group. These results suggest that various ethnic groups could metabolize haloperidol and reduced haloperidol differently.

Original language	English
Pages (from-to)	193-202
Number of pages	10
Journal	Progress in Neuropsychopharmacology and Biological Psychiatry
Volume	16
Issue number	2
DOIs	https://doi.org/10.1016/0278-5846(92)90070-U
State	Published - Mar 1992

Keywords

ethnicity
haloperidol
reduced haloperidol

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10.1016/0278-5846(92)90070-U

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Jann, M. W., Wen-Ho, C., Lam, Y. W. F., Hwu, H. G., Hsin-Nan, L., Horng, C., Chen, T. Y., Shih-Ku, L., Ching-Piao, C., Davis, C. M., Ereshefsky, L., Saklad, S. R., Richards, A. L., & Scholteis, W. M. (1992). Comparison of haloperidol and reduced haloperidol plasma levels in four different ethnic populations. Progress in Neuropsychopharmacology and Biological Psychiatry, 16(2), 193-202. https://doi.org/10.1016/0278-5846(92)90070-U

@article{efb9215da9634522a3e3424f401d9baf,

title = "Comparison of haloperidol and reduced haloperidol plasma levels in four different ethnic populations",

abstract = "1. 1. Plasma haloperidol and reduced haloperidol concentration were measured in four ethnic populations. 2. 2. Plasma samples were obtained under steady-state conditions and obtained 10-12 hours post bedtime dose and prior to the morning dose. 3. 3. Haloperidol and reduced haloperidol plasma levels were assayed by radioimmunoassay and liquid chromatography. 4. 4. A wide interpatient variability between haloperidol dose and plasma concentration was observed for each ethnic group. 5. 5. The Chinese group differed from the other ethnic populations. 6. 6. A nonlinear relationship was observed between haloperidol and reduced haloperidol plasma levels in each ethnic group. Further, the relationship of haloperidol to reduced haloperidol plasma levels differed for each ethnic group. These results suggest that various ethnic groups could metabolize haloperidol and reduced haloperidol differently.",

keywords = "ethnicity, haloperidol, reduced haloperidol",

author = "Jann, {Michael W.} and Chang Wen-Ho and Lam, {Y. W.Francis} and Hwu, {Hai G.} and Lin Hsin-Nan and Chen Horng and Chen, {Teng Y.} and Lin Shih-Ku and Chien Ching-Piao and Davis, {Chester M.} and Larry Ereshefsky and Saklad, {Stephen R.} and Richards, {Ann L.} and Scholteis, {William M.}",

note = "Funding Information: Supported bY grant NSC 79-412-B109-01 from the National Taipei City Government, Taiwan, Republic of China.",

year = "1992",

month = mar,

doi = "10.1016/0278-5846(92)90070-U",

language = "English",

volume = "16",

pages = "193--202",

journal = "Progress in Neuropsychopharmacology and Biological Psychiatry",

issn = "0278-5846",

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number = "2",

}

Jann, MW, Wen-Ho, C, Lam, YWF, Hwu, HG, Hsin-Nan, L, Horng, C, Chen, TY, Shih-Ku, L, Ching-Piao, C, Davis, CM, Ereshefsky, L, Saklad, SR, Richards, AL & Scholteis, WM 1992, 'Comparison of haloperidol and reduced haloperidol plasma levels in four different ethnic populations', Progress in Neuropsychopharmacology and Biological Psychiatry, vol. 16, no. 2, pp. 193-202. https://doi.org/10.1016/0278-5846(92)90070-U

TY - JOUR

T1 - Comparison of haloperidol and reduced haloperidol plasma levels in four different ethnic populations

AU - Jann, Michael W.

AU - Wen-Ho, Chang

AU - Lam, Y. W.Francis

AU - Hwu, Hai G.

AU - Hsin-Nan, Lin

AU - Horng, Chen

AU - Chen, Teng Y.

AU - Shih-Ku, Lin

AU - Ching-Piao, Chien

AU - Davis, Chester M.

AU - Ereshefsky, Larry

AU - Saklad, Stephen R.

AU - Richards, Ann L.

AU - Scholteis, William M.

N1 - Funding Information: Supported bY grant NSC 79-412-B109-01 from the National Taipei City Government, Taiwan, Republic of China.

PY - 1992/3

Y1 - 1992/3

N2 - 1. 1. Plasma haloperidol and reduced haloperidol concentration were measured in four ethnic populations. 2. 2. Plasma samples were obtained under steady-state conditions and obtained 10-12 hours post bedtime dose and prior to the morning dose. 3. 3. Haloperidol and reduced haloperidol plasma levels were assayed by radioimmunoassay and liquid chromatography. 4. 4. A wide interpatient variability between haloperidol dose and plasma concentration was observed for each ethnic group. 5. 5. The Chinese group differed from the other ethnic populations. 6. 6. A nonlinear relationship was observed between haloperidol and reduced haloperidol plasma levels in each ethnic group. Further, the relationship of haloperidol to reduced haloperidol plasma levels differed for each ethnic group. These results suggest that various ethnic groups could metabolize haloperidol and reduced haloperidol differently.

AB - 1. 1. Plasma haloperidol and reduced haloperidol concentration were measured in four ethnic populations. 2. 2. Plasma samples were obtained under steady-state conditions and obtained 10-12 hours post bedtime dose and prior to the morning dose. 3. 3. Haloperidol and reduced haloperidol plasma levels were assayed by radioimmunoassay and liquid chromatography. 4. 4. A wide interpatient variability between haloperidol dose and plasma concentration was observed for each ethnic group. 5. 5. The Chinese group differed from the other ethnic populations. 6. 6. A nonlinear relationship was observed between haloperidol and reduced haloperidol plasma levels in each ethnic group. Further, the relationship of haloperidol to reduced haloperidol plasma levels differed for each ethnic group. These results suggest that various ethnic groups could metabolize haloperidol and reduced haloperidol differently.

KW - ethnicity

KW - haloperidol

KW - reduced haloperidol

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U2 - 10.1016/0278-5846(92)90070-U

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SP - 193

EP - 202

JO - Progress in Neuropsychopharmacology and Biological Psychiatry

JF - Progress in Neuropsychopharmacology and Biological Psychiatry

IS - 2

ER -

Comparison of haloperidol and reduced haloperidol plasma levels in four different ethnic populations

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