TY - JOUR
T1 - Comparison of five tandem repeat loci between humans and chimpanzees
AU - Ely, John
AU - Deka, Ranjan
AU - Chakraborty, Ranajit
AU - Ferrell, Robert E.
N1 - Funding Information:
We thank Y. Nakamura for providing probes pYNZ2, pYNZ22, and pMLAJ1, D. R. Higgs for providing probe pa5'HVR.14, and D. Yan- dell for providing probe p68RS2.0 and the sequence data to select PCR primers for the Rbl locus. This research was partially supported by NIH Grant RR-03577 to R.E.F.; J.E. was partially supported by NIH Grants RR-04301 and RR-05080. R.D. was supported by University of Pittsburgh CRDF Grant 5-33344. We thank Dr. Diane Sapphire for an illuminating discussion of sampling bias.
PY - 1992/11
Y1 - 1992/11
N2 - Five tandem repeat loci were studied in humans and chimpanzees using VNTR probes derived from human DNA. Shared alleles were found at three loci and were often the modal allele in one species but never in both. There was no difference in the mean number of alleles per locus. However, these species exhibited substantially different levels of gene diversity, with chimpanzees monomorphic at two loci. Evidence of reduced variability in chimpanzees corroborates earlier comparisons using isozymes and plasma proteins. Molecular mechanisms, population dynamics, or both may be responsible for these differences. Equal numbers of alleles per locus may reflect high mutation rates. By one test, chimpanzees were out of equilibrium at one locus, which may reflect a typing error or population substructure. The long divergence time, and the high probability of backward mutations, precludes accurate estimation of genetic distance between these species.
AB - Five tandem repeat loci were studied in humans and chimpanzees using VNTR probes derived from human DNA. Shared alleles were found at three loci and were often the modal allele in one species but never in both. There was no difference in the mean number of alleles per locus. However, these species exhibited substantially different levels of gene diversity, with chimpanzees monomorphic at two loci. Evidence of reduced variability in chimpanzees corroborates earlier comparisons using isozymes and plasma proteins. Molecular mechanisms, population dynamics, or both may be responsible for these differences. Equal numbers of alleles per locus may reflect high mutation rates. By one test, chimpanzees were out of equilibrium at one locus, which may reflect a typing error or population substructure. The long divergence time, and the high probability of backward mutations, precludes accurate estimation of genetic distance between these species.
UR - http://www.scopus.com/inward/record.url?scp=0026499649&partnerID=8YFLogxK
U2 - 10.1016/S0888-7543(05)80170-3
DO - 10.1016/S0888-7543(05)80170-3
M3 - Article
C2 - 1427897
AN - SCOPUS:0026499649
VL - 14
SP - 692
EP - 698
JO - Genomics
JF - Genomics
SN - 0888-7543
IS - 3
ER -