Comparing the 'family set' approach to estimate heritability with other conventional estimators: A monte carlo simulation

Alvaro Rodríguez, Ranajit Chakraborty, William J. Schull

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A Monte Carlo simulation is performed to study the distribution of the family set estimators of heritability and to compare their performance with that of some conventional estimators used in human genetics. Comparisons of statistical properties among the two family set estimators (one based on the partial regression coefficients of the index's values on those of sib and cousin, respectively, and one based on the variances of the differences between the phenotypic values of index and cousin and of index and sib) and the three conventional estimators (one based on regression of index value on midparental value, another based on the sib-sib correlation, and the last one based on the index-cousin correlation) are also made under two genetic models.

Original languageEnglish
Pages (from-to)192-200
Number of pages9
JournalHuman Heredity
Volume30
Issue number3
DOIs
StatePublished - 1 Jan 1980

Fingerprint

Genetic Models
Medical Genetics

Keywords

  • Bias of estimators
  • Family set
  • Heritability
  • Monte Carlo simulation
  • Statistical efficiency

Cite this

Rodríguez, Alvaro ; Chakraborty, Ranajit ; Schull, William J. / Comparing the 'family set' approach to estimate heritability with other conventional estimators : A monte carlo simulation. In: Human Heredity. 1980 ; Vol. 30, No. 3. pp. 192-200.
@article{ca16cb3fc99f405abdec1dd3aa11d5b4,
title = "Comparing the 'family set' approach to estimate heritability with other conventional estimators: A monte carlo simulation",
abstract = "A Monte Carlo simulation is performed to study the distribution of the family set estimators of heritability and to compare their performance with that of some conventional estimators used in human genetics. Comparisons of statistical properties among the two family set estimators (one based on the partial regression coefficients of the index's values on those of sib and cousin, respectively, and one based on the variances of the differences between the phenotypic values of index and cousin and of index and sib) and the three conventional estimators (one based on regression of index value on midparental value, another based on the sib-sib correlation, and the last one based on the index-cousin correlation) are also made under two genetic models.",
keywords = "Bias of estimators, Family set, Heritability, Monte Carlo simulation, Statistical efficiency",
author = "Alvaro Rodr{\'i}guez and Ranajit Chakraborty and Schull, {William J.}",
year = "1980",
month = "1",
day = "1",
doi = "10.1159/000153126",
language = "English",
volume = "30",
pages = "192--200",
journal = "Human Heredity",
issn = "0001-5652",
publisher = "S. Karger AG",
number = "3",

}

Comparing the 'family set' approach to estimate heritability with other conventional estimators : A monte carlo simulation. / Rodríguez, Alvaro; Chakraborty, Ranajit; Schull, William J.

In: Human Heredity, Vol. 30, No. 3, 01.01.1980, p. 192-200.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Comparing the 'family set' approach to estimate heritability with other conventional estimators

T2 - A monte carlo simulation

AU - Rodríguez, Alvaro

AU - Chakraborty, Ranajit

AU - Schull, William J.

PY - 1980/1/1

Y1 - 1980/1/1

N2 - A Monte Carlo simulation is performed to study the distribution of the family set estimators of heritability and to compare their performance with that of some conventional estimators used in human genetics. Comparisons of statistical properties among the two family set estimators (one based on the partial regression coefficients of the index's values on those of sib and cousin, respectively, and one based on the variances of the differences between the phenotypic values of index and cousin and of index and sib) and the three conventional estimators (one based on regression of index value on midparental value, another based on the sib-sib correlation, and the last one based on the index-cousin correlation) are also made under two genetic models.

AB - A Monte Carlo simulation is performed to study the distribution of the family set estimators of heritability and to compare their performance with that of some conventional estimators used in human genetics. Comparisons of statistical properties among the two family set estimators (one based on the partial regression coefficients of the index's values on those of sib and cousin, respectively, and one based on the variances of the differences between the phenotypic values of index and cousin and of index and sib) and the three conventional estimators (one based on regression of index value on midparental value, another based on the sib-sib correlation, and the last one based on the index-cousin correlation) are also made under two genetic models.

KW - Bias of estimators

KW - Family set

KW - Heritability

KW - Monte Carlo simulation

KW - Statistical efficiency

UR - http://www.scopus.com/inward/record.url?scp=0018862822&partnerID=8YFLogxK

U2 - 10.1159/000153126

DO - 10.1159/000153126

M3 - Article

C2 - 7358408

AN - SCOPUS:0018862822

VL - 30

SP - 192

EP - 200

JO - Human Heredity

JF - Human Heredity

SN - 0001-5652

IS - 3

ER -