TY - JOUR
T1 - Comparative study of genetic variation at 15 STR loci in three isolated populations of the Bosnian mountain area
AU - Marjanovic, D.
AU - Kapur, L.
AU - Drobnic, K.
AU - Budowle, B.
AU - Pojskic, N.
AU - Hadziselimovic, R.
PY - 2004/2
Y1 - 2004/2
N2 - Fifteen autosomal STR loci (D3S1358, TH01, D21S11, D18S51, Penta E, D5S818, D13S317, D7S820, D16S539, CSF1PO, Penta D, VWA, D8S1179, TPOX, and FGA) were studied in three geographically close but isolated populations from the Bosnian mountain area. The three villages are Bobovica, Dejcici, and Lukomir. DNA was obtained from 83 individuals, and the allele frequencies and genetic diversity among the three sample groups were compared. In addition, seven of the STR loci (CSF1PO, D13S317, D3S1358, D5S818, D7S820, FGA, TH01) were used in a comparative population analysis of the Bjelašnica-Treskavica region and the Adriatic islands of Brac, Hvar, and Korcula. Although the sample sizes are relatively small, the observed variation within any of the small isolated populations is high and comparable to less isolated groups. In addition, even though the populations are geographically isolated, the STR data are similar among the populations. The most significant frequency differences were observed at the TH01 locus. Although the specific allele distributions in any untyped population cannot be determined a priori, we find support for a high degree of diversity for the STR loci in most populations. In addition, the multiple locus profile is highly informative not only for various population studies but also for forensic studies, even when specific population data are not available.
AB - Fifteen autosomal STR loci (D3S1358, TH01, D21S11, D18S51, Penta E, D5S818, D13S317, D7S820, D16S539, CSF1PO, Penta D, VWA, D8S1179, TPOX, and FGA) were studied in three geographically close but isolated populations from the Bosnian mountain area. The three villages are Bobovica, Dejcici, and Lukomir. DNA was obtained from 83 individuals, and the allele frequencies and genetic diversity among the three sample groups were compared. In addition, seven of the STR loci (CSF1PO, D13S317, D3S1358, D5S818, D7S820, FGA, TH01) were used in a comparative population analysis of the Bjelašnica-Treskavica region and the Adriatic islands of Brac, Hvar, and Korcula. Although the sample sizes are relatively small, the observed variation within any of the small isolated populations is high and comparable to less isolated groups. In addition, even though the populations are geographically isolated, the STR data are similar among the populations. The most significant frequency differences were observed at the TH01 locus. Although the specific allele distributions in any untyped population cannot be determined a priori, we find support for a high degree of diversity for the STR loci in most populations. In addition, the multiple locus profile is highly informative not only for various population studies but also for forensic studies, even when specific population data are not available.
KW - Adriatic islands
KW - Bjelašnica-Treskavica region
KW - Bosnian mountain area
KW - CSF1PO
KW - D13S317
KW - D16S539
KW - D18S51
KW - D21S11
KW - D3S1358
KW - D5S818
KW - D7S820
KW - D8S1179
KW - Genetic distance
KW - Heterozygosity
KW - Isolated population
KW - Penta D
KW - Penta E
KW - Short Tandem Repeat (STR)
KW - TH01
KW - TPOX
KW - VWA
UR - http://www.scopus.com/inward/record.url?scp=2942670649&partnerID=8YFLogxK
U2 - 10.1353/hub.2004.0024
DO - 10.1353/hub.2004.0024
M3 - Article
C2 - 15222678
AN - SCOPUS:2942670649
VL - 76
SP - 15
EP - 31
JO - Human Biology
JF - Human Biology
SN - 0018-7143
IS - 1
ER -