Abstract
The general objective of this study was to compare the relative permeability of a few representative chemicals across vaginal, vestibule and uterine tissues, using the rabbit doe as the experimental animal. Mounted tissue, in a standard permeability chamber employing radiolabelled glycerol, sulfate and estradiol, was the basis of the experimental design. All three tissues showed a permeability coefficient of approximately 7x10-6 cm/s. No apparent preference in absorption was observed despite the considerable difference in water solubility of the probe chemicals.
Original language | English |
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Pages (from-to) | 430-434 |
Number of pages | 5 |
Journal | S.T.P. Pharma Sciences |
Volume | 6 |
Issue number | 6 |
State | Published - 1 Nov 1996 |
Keywords
- Estradiol
- Glycerol
- Sulfate
- Uterine permeability
- Vaginal drug delivery
- Vaginal permeability