Comparative permeabilities of some solutes across the uterus, vagina and vestibule of the rabbit doe

E. M. Slovin, J. R. Robinson

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The general objective of this study was to compare the relative permeability of a few representative chemicals across vaginal, vestibule and uterine tissues, using the rabbit doe as the experimental animal. Mounted tissue, in a standard permeability chamber employing radiolabelled glycerol, sulfate and estradiol, was the basis of the experimental design. All three tissues showed a permeability coefficient of approximately 7x10-6 cm/s. No apparent preference in absorption was observed despite the considerable difference in water solubility of the probe chemicals.

Original languageEnglish
Pages (from-to)430-434
Number of pages5
JournalS.T.P. Pharma Sciences
Issue number6
StatePublished - 1 Nov 1996



  • Estradiol
  • Glycerol
  • Sulfate
  • Uterine permeability
  • Vaginal drug delivery
  • Vaginal permeability

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