Comparative permeabilities of some solutes across the uterus, vagina and vestibule of the rabbit doe

E. M. Slovin; J. R. Robinson

Comparative permeabilities of some solutes across the uterus, vagina and vestibule of the rabbit doe

E. M. Slovin, J. R. Robinson

Research output: Contribution to journal › Article › peer-review

Abstract

The general objective of this study was to compare the relative permeability of a few representative chemicals across vaginal, vestibule and uterine tissues, using the rabbit doe as the experimental animal. Mounted tissue, in a standard permeability chamber employing radiolabelled glycerol, sulfate and estradiol, was the basis of the experimental design. All three tissues showed a permeability coefficient of approximately 7x10^-6 cm/s. No apparent preference in absorption was observed despite the considerable difference in water solubility of the probe chemicals.

Original language	English
Pages (from-to)	430-434
Number of pages	5
Journal	S.T.P. Pharma Sciences
Volume	6
Issue number	6
State	Published - 1 Nov 1996

Keywords

Estradiol
Glycerol
Sulfate
Uterine permeability
Vaginal drug delivery
Vaginal permeability

Cite this

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AB - The general objective of this study was to compare the relative permeability of a few representative chemicals across vaginal, vestibule and uterine tissues, using the rabbit doe as the experimental animal. Mounted tissue, in a standard permeability chamber employing radiolabelled glycerol, sulfate and estradiol, was the basis of the experimental design. All three tissues showed a permeability coefficient of approximately 7x10-6 cm/s. No apparent preference in absorption was observed despite the considerable difference in water solubility of the probe chemicals.

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KW - Uterine permeability

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KW - Vaginal permeability

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ER -

Comparative permeabilities of some solutes across the uterus, vagina and vestibule of the rabbit doe

Abstract

Keywords

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